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Open AccessArticle

Catalase and Ascorbate Peroxidase in Euglenozoan Protists

1
Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 370 05 České Budějovice (Budweis), Czech Republic
2
Faculty of Natural Sciences, Comenius University, 841 04 Bratislava, Slovakia
3
Faculty of Science, Charles University, BIOCEV, 128 00 Prague, Czech Republic
4
Life Science Research Centre, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
5
Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, 119435 Moscow, Russia
6
Faculty of Sciences, University of South Bohemia, 370 05 České Budějovice (Budweis), Czech Republic
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Pathogens 2020, 9(4), 317; https://doi.org/10.3390/pathogens9040317
Received: 27 March 2020 / Revised: 21 April 2020 / Accepted: 22 April 2020 / Published: 24 April 2020
(This article belongs to the Special Issue Kinetoplastid Phylogenomics and Evolution)
In this work, we studied the biochemical properties and evolutionary histories of catalase (CAT) and ascorbate peroxidase (APX), two central enzymes of reactive oxygen species detoxification, across the highly diverse clade Eugenozoa. This clade encompasses free-living phototrophic and heterotrophic flagellates, as well as obligate parasites of insects, vertebrates, and plants. We present evidence of several independent acquisitions of CAT by horizontal gene transfers and evolutionary novelties associated with the APX presence. We posit that Euglenozoa recruit these detoxifying enzymes for specific molecular tasks, such as photosynthesis in euglenids and membrane-bound peroxidase activity in kinetoplastids and some diplonemids. View Full-Text
Keywords: Euglenozoa; ascorbate peroxidase; catalase; enzymatic activity; phylogeny Euglenozoa; ascorbate peroxidase; catalase; enzymatic activity; phylogeny
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Škodová-Sveráková, I.; Záhonová, K.; Bučková, B.; Füssy, Z.; Yurchenko, V.; Lukeš, J. Catalase and Ascorbate Peroxidase in Euglenozoan Protists. Pathogens 2020, 9, 317.

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