Next Article in Journal
Modelling a Silent Epidemic: A Review of the In Vitro Models of Latent Tuberculosis
Previous Article in Journal
SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation

Hsp90 Interacts with the Bacterial Effector NleH1

Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA
Author to whom correspondence should be addressed.
Pathogens 2018, 7(4), 87;
Received: 26 September 2018 / Revised: 31 October 2018 / Accepted: 11 November 2018 / Published: 13 November 2018
Enterohemorrhagic Escherichia coli (EHEC) utilizes a type III secretion system (T3SS) to inject effector proteins into host cells. The EHEC NleH1 effector inhibits the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway by reducing the nuclear translocation of the ribosomal protein S3 (RPS3). NleH1 prevents RPS3 phosphorylation by the IκB kinase-β (IKKβ). IKKβ is a central kinase in the NF-κB pathway, yet NleH1 only restricts the phosphorylation of a subset of the IKKβ substrates. We hypothesized that a protein cofactor might dictate this inhibitory specificity. We determined that heat shock protein 90 (Hsp90) interacts with both IKKβ and NleH1 and that inhibiting Hsp90 activity reduces RPS3 nuclear translocation. View Full-Text
Keywords: E. coli; Hsp90; NleH1; RPS3 E. coli; Hsp90; NleH1; RPS3
Show Figures

Figure 1

MDPI and ACS Style

Wu, M.; Hardwidge, P.R. Hsp90 Interacts with the Bacterial Effector NleH1. Pathogens 2018, 7, 87.

AMA Style

Wu M, Hardwidge PR. Hsp90 Interacts with the Bacterial Effector NleH1. Pathogens. 2018; 7(4):87.

Chicago/Turabian Style

Wu, Miaomiao, and Philip R. Hardwidge. 2018. "Hsp90 Interacts with the Bacterial Effector NleH1" Pathogens 7, no. 4: 87.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop