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Pathogens 2017, 6(2), 26;

IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns

Department of Gynecology and Obstetrics, Faculty of Medicine, Federal University of Goias (UFG), Goiania GO 74045-155, Brazil
Laboratory of Immunology of Clinical Hospital of UFG, Goiania GO 74605-020, Brazil
Department of Gynecology, Faculty of Medicine, Federal University of São Paulo, São Paulo SP 04039-032, Brazil
Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, UFG, Goiania GO 74605-450, Brazil
Author to whom correspondence should be addressed.
Received: 7 March 2017 / Revised: 9 June 2017 / Accepted: 11 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Toxoplasma gondii Infection)
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The goal of this study was to investigate the importance of IgG avidity testing in newborns (NBs) diagnosed with early congenital toxoplasmosis. We collected samples from 88 puerperae infected by Toxoplasma gondii (T. gondii) and their NBs (48 acutely-infected puerperae (AIP) and 40 chronically-infected puerperae (CIP)), from two public maternity hospitals in Goiania city, Goias, Brazil, from 2010 to 2015. Specific anti-T. gondii IgM and IgG serum levels and IgG avidity tests were evaluated using chemiluminescence. Congenital toxoplasmosis was observed in 66.66% (n = 32) of NBs with AIP, 94.1% presenting low avidity (LA) and 51.61% presenting high avidity (HA) test results. The IgG and IgM levels of NBs with LA and their puerperae were higher in comparison with HA NBs and puerperae (p = 0.0001). The avidity tests showed 100% specificity and 50% sensitivity (p = 0.0001). NBs with LA had a 15-fold increased risk of developing congenital toxoplasmosis in comparison with HA NBs. The IgG avidity test could be used to assist in early congenital toxoplasmosis diagnoses in NBs and LA, identifying a greater probability of vertical transmission. View Full-Text
Keywords: congenital toxoplasmosis; IgG avidity; diagnoses; newborns; puerperae congenital toxoplasmosis; IgG avidity; diagnoses; newborns; puerperae

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Fonseca, Z.C.; Rodrigues, I.M.X.; Melo, N.C.; Avelar, J.B.; Castro, A.M.; Avelino, M.M. IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns. Pathogens 2017, 6, 26.

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