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Pathogens 2013, 2(1), 33-54; https://doi.org/10.3390/pathogens2010033

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

1
Department of Laboratory Medicine & Pathobiology, University of Toronto, Canada
2
Department of Pathology & Laboratory Medicine, The University of Calgary, Calgary, AB, Canada
3
Department of Microbiology, Immunology, and Infectious Diseases, The University of Calgary, Diagnostic & Scientific Centre, Room 1W-416, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada
*
Author to whom correspondence should be addressed.
Received: 8 December 2012 / Revised: 18 January 2013 / Accepted: 23 January 2013 / Published: 4 February 2013
(This article belongs to the Special Issue Host-Parasite Interactions)
Full-Text   |   PDF [623 KB, uploaded 4 February 2013]   |  

Abstract

Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to traditionally efficacious compounds like chloroquine. View Full-Text
Keywords: malaria; hsp90; antimalarial resistance malaria; hsp90; antimalarial resistance
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Shahinas, D.; Folefoc, A.; Pillai, D.R. Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance. Pathogens 2013, 2, 33-54.

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