Next Article in Journal
Nanopore Workflow for Grapevine Viroid Surveillance in Kazakhstan: Bypassing rRNA Depletion Through Non-Canonical Priming
Previous Article in Journal
Antimicrobial Potential of Bee-Derived Products: Insights into Honey, Propolis and Bee Venom
Previous Article in Special Issue
Molecular Differentiation and Detection of AMR Genes from Nosocomial Staphylococcus spp.
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 14
Issue 8
10.3390/pathogens14080781
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Brief Report

One-Shot, One Opportunity: Retrospective Observational Study on Long-Acting Antibiotics for SSTIs in the Emergency Room—A Real-Life Experience

by
Giacomo Ciusa
1,†,
Giuseppe Pipitone
1,*,†,
Alessandro Mancuso
1,2,
Stefano Agrenzano
1,
Claudia Imburgia
1,
Agostino Massimo Geraci
3,
Alberto D’Alcamo
3,
Luisa Moscarelli
4,
Antonio Cascio
5 and
Chiara Iaria
1
1
Infectious Diseases Unit, ARNAS Civico-Di Cristina Hospital, 90100 Palermo, Italy
2
Infectious Diseases Unit, Umberto I Public Hospital, 96100 Siracusa, Italy
3
Emergency Room, ARNAS Civico-Di Cristina Hospital, 90100 Palermo, Italy
4
Pharmacy Unit, ARNAS Civico-Di Cristina Hospital, 90100 Palermo, Italy
5
Infectious Diseases Unit, P. Giaccone University Hospital, 90100 Palermo, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pathogens 2025, 14(8), 781; https://doi.org/10.3390/pathogens14080781
Submission received: 22 July 2025 / Revised: 5 August 2025 / Accepted: 6 August 2025 / Published: 6 August 2025
(This article belongs to the Special Issue Nosocomial Infections and Antimicrobial Resistance: Challenges and Solutions)
Versions Notes

Abstract

Background: Skin and soft tissue infections (SSTIs) are a major cause of emergency room (ER) visits and hospitalizations. Long-acting lipoglycopeptides (LALs), such as dalbavancin and oritavancin, offer potential for early discharge and outpatient management, especially in patients at risk for methicillin-resistant Staphylococcus aureus (MRSA) or with comorbidities. Methods: We conducted a retrospective observational cohort study from March to December 2024 in an Italian tertiary-care hospital. Adult patients treated in the ER with a single dose of dalbavancin (1500 mg) or oritavancin (1200 mg) for SSTIs were included. Demographic, clinical, and laboratory data were collected. Follow-up evaluations were performed at 14 and 30 days post-treatment to assess outcomes. Results: Nineteen patients were enrolled (median age 59 years; 53% female). Most had lower limb involvement and elevated inflammatory markers. Three patients (16%) were septic. Fourteen patients (74%) were discharged without hospital admission; hospitalization in the remaining cases was due to comorbidities rather than SSTI severity. No adverse drug reactions were observed. At 14 days, 84% of patients had clinical resolution; only 10% had recurrence by day 30, with no mortality nor readmission reported. Conclusions: LALs appear effective and well-tolerated in the ER setting, supporting early discharge and reducing healthcare burden. Broader use may require structured care pathways and multidisciplinary coordination.
Keywords: long-acting antibiotics; emergency room; dalbavancin; oritavancin; skin and soft tissue infection long-acting antibiotics; emergency room; dalbavancin; oritavancin; skin and soft tissue infection

Share and Cite

MDPI and ACS Style

Ciusa, G.; Pipitone, G.; Mancuso, A.; Agrenzano, S.; Imburgia, C.; Geraci, A.M.; D’Alcamo, A.; Moscarelli, L.; Cascio, A.; Iaria, C. One-Shot, One Opportunity: Retrospective Observational Study on Long-Acting Antibiotics for SSTIs in the Emergency Room—A Real-Life Experience. Pathogens 2025, 14, 781. https://doi.org/10.3390/pathogens14080781

AMA Style

Ciusa G, Pipitone G, Mancuso A, Agrenzano S, Imburgia C, Geraci AM, D’Alcamo A, Moscarelli L, Cascio A, Iaria C. One-Shot, One Opportunity: Retrospective Observational Study on Long-Acting Antibiotics for SSTIs in the Emergency Room—A Real-Life Experience. Pathogens. 2025; 14(8):781. https://doi.org/10.3390/pathogens14080781

Chicago/Turabian Style

Ciusa, Giacomo, Giuseppe Pipitone, Alessandro Mancuso, Stefano Agrenzano, Claudia Imburgia, Agostino Massimo Geraci, Alberto D’Alcamo, Luisa Moscarelli, Antonio Cascio, and Chiara Iaria. 2025. "One-Shot, One Opportunity: Retrospective Observational Study on Long-Acting Antibiotics for SSTIs in the Emergency Room—A Real-Life Experience" Pathogens 14, no. 8: 781. https://doi.org/10.3390/pathogens14080781

APA Style

Ciusa, G., Pipitone, G., Mancuso, A., Agrenzano, S., Imburgia, C., Geraci, A. M., D’Alcamo, A., Moscarelli, L., Cascio, A., & Iaria, C. (2025). One-Shot, One Opportunity: Retrospective Observational Study on Long-Acting Antibiotics for SSTIs in the Emergency Room—A Real-Life Experience. Pathogens, 14(8), 781. https://doi.org/10.3390/pathogens14080781

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop