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Volume 13
Issue 5
10.3390/pathogens13050416
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Article

Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions

by
Pedro B. Borba
1,
Jamile Lago
2,
Tainã Lago
2,
Mariana Araújo-Pereira
3,4,
Artur T. L. Queiroz
1,3,4,
Hernane S. Barud
5,
Lucas P. Carvalho
1,2,6,
Paulo R. L. Machado
2,6,
Edgar M. Carvalho
1,2,6 and
Camila I. de Oliveira
1,6,*
1
Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, BA, Brazil
2
Serviço de Imunologia, HUPES-UFBA, Salvador 40110-060, BA, Brazil
3
Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative), Salvador 41720-200, BA, Brazil
4
Instituto de Pesquisa Clínica e Translacional (IPCT), UniFTC, Salvador 41720-200, BA, Brazil
5
Laboratório de BioPolímeros e Biomateriais, Uniara, Araraquara 14801-340, SP, Brazil
6
INCT—Instituto de Investigação em Doenças Tropicais, Salvador 40110-040, BA, Brazil
*
Author to whom correspondence should be addressed.
Pathogens 2024, 13(5), 416; https://doi.org/10.3390/pathogens13050416
Submission received: 7 February 2024 / Revised: 24 April 2024 / Accepted: 9 May 2024 / Published: 16 May 2024
(This article belongs to the Special Issue Host Immune Responses in the Control of Leishmania Infection and New Forms of Therapy for Tegumentary Leishmaniasis)
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Abstract

Leishmaniasis, caused by Leishmania parasites, is a neglected tropical disease and Cutaneous Leishmaniasis (CL) is the most common form. Despite the associated toxicity and adverse effects, Meglumine antimoniate (MA) remains the first-choice treatment for CL in Brazil, pressing the need for the development of better alternatives. Bacterial NanoCellulose (BNC), a biocompatible nanomaterial, has unique properties regarding wound healing. In a previous study, we showed that use of topical BNC + systemic MA significantly increased the cure rate of CL patients, compared to treatment with MA alone. Herein, we performed a study comparing the combination of a wound dressing (BNC or placebo) plus systemic MA versus systemic MA alone, in CL caused by Leishmania braziliensis. We show that patients treated with the combination treatment (BNC or placebo) + MA showed improved cure rates and decreased need for rescue treatment, although differences compared to controls (systemic MA alone) were not significant. However, the overall time-to-cure was significantly lower in groups treated with the combination treatment (BNC+ systemic MA or placebo + systemic MA) in comparison to controls (MA alone), indicating that the use of a wound dressing improves CL treatment outcome. Assessment of the immune response in peripheral blood showed an overall downmodulation in the inflammatory landscape and a significant decrease in the production of IL-1a (p < 0.05) in patients treated with topical BNC + systemic MA. Our results show that the application of wound dressings to CL lesions can improve chemotherapy outcome in CL caused by L. braziliensis.
Keywords: Leishmania braziliensis; skin lesion; meglumine antimoniate; topical therapy; wound dressing Leishmania braziliensis; skin lesion; meglumine antimoniate; topical therapy; wound dressing

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MDPI and ACS Style

Borba, P.B.; Lago, J.; Lago, T.; Araújo-Pereira, M.; Queiroz, A.T.L.; Barud, H.S.; Carvalho, L.P.; Machado, P.R.L.; Carvalho, E.M.; de Oliveira, C.I. Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions. Pathogens 2024, 13, 416. https://doi.org/10.3390/pathogens13050416

AMA Style

Borba PB, Lago J, Lago T, Araújo-Pereira M, Queiroz ATL, Barud HS, Carvalho LP, Machado PRL, Carvalho EM, de Oliveira CI. Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions. Pathogens. 2024; 13(5):416. https://doi.org/10.3390/pathogens13050416

Chicago/Turabian Style

Borba, Pedro B., Jamile Lago, Tainã Lago, Mariana Araújo-Pereira, Artur T. L. Queiroz, Hernane S. Barud, Lucas P. Carvalho, Paulo R. L. Machado, Edgar M. Carvalho, and Camila I. de Oliveira. 2024. "Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions" Pathogens 13, no. 5: 416. https://doi.org/10.3390/pathogens13050416

APA Style

Borba, P. B., Lago, J., Lago, T., Araújo-Pereira, M., Queiroz, A. T. L., Barud, H. S., Carvalho, L. P., Machado, P. R. L., Carvalho, E. M., & de Oliveira, C. I. (2024). Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions. Pathogens, 13(5), 416. https://doi.org/10.3390/pathogens13050416

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