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Pathogens
Volume 11
Issue 5
10.3390/pathogens11050526
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Case Report

Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection

by
Kazuki Imai
1,
Takayoshi Sumioka
1,*,
Hiroki Iwanishi
1,
Yukihisa Takada
1,
Shin’ichi Murata
2,
Ryuta Iwamoto
2,
Yuka Okada
1 and
Shizuya Saika
1
1
Department of Ophthalmology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan
2
Department of Clinical Pathology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan
*
Author to whom correspondence should be addressed.
Pathogens 2022, 11(5), 526; https://doi.org/10.3390/pathogens11050526
Submission received: 4 February 2022 / Revised: 11 April 2022 / Accepted: 28 April 2022 / Published: 29 April 2022
(This article belongs to the Special Issue Advances in Ocular Surface Infections)
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Abstract

Background: Corneal infection of Colletotrichum gloeosporioides is uncommon and usually limited to the anterior stroma. However, we observed a case of corneal stromal perforation caused by this fungus under a compromised condition. Case: A 73-year-old woman consulted us with a severe corneal ulceration. She was a tangerine orange farmer who suffered from rheumatoid arthritis for more than ten years. Before consultation with us, she received pterygium excision in her right eye. She then developed a corneal ulceration and received topical glucocorticoid therapy upon diagnosis of rheumatoid arthritis-related stromal ulcer in the eye. At the first consultation with us, a corneal ulceration was observed in the inferotemporal area of her right cornea. Biological examination detected a filamentous fungus, Colletotrichum gloeosporioides. Topical and systemic antifungal treatments were not significantly effective. Fourteen days after consultation, the lesion grew worse, leading to stromal perforation, which was treated by therapeutic penetrating keratoplasty using a preserved corneal button. Conclusions: Topical glucocorticoid could accelerate the growth of Colletotrichum gloeosporioides before diagnosis, even though the primary cause of corneal ulceration development might be rheumatoid arthritis.
Keywords: Colletotrichum gloeosporioides; corneal ulcer; glucocorticoid; therapeutic penetrating keratoplasty Colletotrichum gloeosporioides; corneal ulcer; glucocorticoid; therapeutic penetrating keratoplasty

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MDPI and ACS Style

Imai, K.; Sumioka, T.; Iwanishi, H.; Takada, Y.; Murata, S.; Iwamoto, R.; Okada, Y.; Saika, S. Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection. Pathogens 2022, 11, 526. https://doi.org/10.3390/pathogens11050526

AMA Style

Imai K, Sumioka T, Iwanishi H, Takada Y, Murata S, Iwamoto R, Okada Y, Saika S. Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection. Pathogens. 2022; 11(5):526. https://doi.org/10.3390/pathogens11050526

Chicago/Turabian Style

Imai, Kazuki, Takayoshi Sumioka, Hiroki Iwanishi, Yukihisa Takada, Shin’ichi Murata, Ryuta Iwamoto, Yuka Okada, and Shizuya Saika. 2022. "Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection" Pathogens 11, no. 5: 526. https://doi.org/10.3390/pathogens11050526

APA Style

Imai, K., Sumioka, T., Iwanishi, H., Takada, Y., Murata, S., Iwamoto, R., Okada, Y., & Saika, S. (2022). Therapeutic Penetrating Keratoplasty in a Case of Corneal Perforation Caused by Colletotrichum gloeosporioides Infection. Pathogens, 11(5), 526. https://doi.org/10.3390/pathogens11050526

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