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Article

Colonization of Group B Streptococcus in Pregnant Women and Their Neonates from a Sri Lankan Hospital

1
Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
2
Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri Lanka
3
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri Lanka
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Kirsty Le Doare and Konstantinos Karampatsas
Pathogens 2022, 11(4), 386; https://doi.org/10.3390/pathogens11040386
Received: 10 March 2022 / Revised: 20 March 2022 / Accepted: 21 March 2022 / Published: 23 March 2022
(This article belongs to the Special Issue Group B-Streptococcus (GBS))
We investigated the molecular epidemiology of Streptococcus agalactiae (Group B Streptococcus, GBS) from carriage in a cohort of pregnant mothers and their respective newborns in a Teaching Hospital in Sri Lanka. GBS vaginal carriage was assessed on pregnant mothers at pre-delivery (n = 250), post-delivery (n = 130), and from peri-rectal swabs of neonates (n = 159) in a prospective study. All colonizing, non-duplicate GBS isolates (n = 60) were analyzed for antimicrobial susceptibilities, capsular serotyping, and whole-genome sequencing (WGS). The percentage of GBS carriage in mothers in the pre-delivery and post-delivery cohorts were 11.2% (n = 28) and 19.2% (n = 25), respectively, and 4.4% (n = 7) in neonates. GBS isolates predominantly belonged to serotype VI (17/60, 28.3%). The isolates spanned across 12 sequence types (STs), with ST1 (24/60, 40%) being the most predominant ST. Concomitant resistance to erythromycin, tetracyclines, and gentamicin was observed in eight strains (13.3%). WGS revealed the presence of antimicrobial resistance genes including ermA (5/60), mefA (1/60), msrD (1/60), and tetLMO (2/60, 28/60, and 1/60, respectively) among 60 strains. The study provides insight into the diversity of vaccine targets of GBS since serotype VI is yet to be covered in the vaccine development program. View Full-Text
Keywords: group B Streptococcus; Streptococcus agalactiae; molecular epidemiology; genome analysis; pregnant women colonization; neonatal colonization group B Streptococcus; Streptococcus agalactiae; molecular epidemiology; genome analysis; pregnant women colonization; neonatal colonization
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MDPI and ACS Style

Sapugahawatte, D.N.; Li, C.; Liyanapathirana, V.; Kandauda, C.; Gihan, C.; Zhu, C.; Lo, N.W.S.; Wong, K.T.; Ip, M. Colonization of Group B Streptococcus in Pregnant Women and Their Neonates from a Sri Lankan Hospital. Pathogens 2022, 11, 386. https://doi.org/10.3390/pathogens11040386

AMA Style

Sapugahawatte DN, Li C, Liyanapathirana V, Kandauda C, Gihan C, Zhu C, Lo NWS, Wong KT, Ip M. Colonization of Group B Streptococcus in Pregnant Women and Their Neonates from a Sri Lankan Hospital. Pathogens. 2022; 11(4):386. https://doi.org/10.3390/pathogens11040386

Chicago/Turabian Style

Sapugahawatte, Dulmini N., Carmen Li, Veranja Liyanapathirana, Chaminda Kandauda, Champika Gihan, Chendi Zhu, Norman W.S. Lo, Kam T. Wong, and Margaret Ip. 2022. "Colonization of Group B Streptococcus in Pregnant Women and Their Neonates from a Sri Lankan Hospital" Pathogens 11, no. 4: 386. https://doi.org/10.3390/pathogens11040386

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