New Corynebacterium Species with the Potential to Produce Diphtheria Toxin

Round 1

Reviewer 1 Report

Good review, which needs some corrections in respect to English language and typos.

Please see the attachment for specific comments

 

Comments for author File: Comments.pdf

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

The manuscript by Prygiel et al. is of interest as it summarize old and new information about different Corynebacterium species. There are only some minor comments.

I did not find the title appropriate for a review. Readers may expect a research article.

Lines 10-11, please rephrase. It is not clear who is lysogen and who has the gene. 

Line 15, the novel species? These species are never mentioned before in the abstract. 

Lines 275-276, please check and rephrase (isolate (?) and isolate KL1196...).

Line 279, C. ulcerans should be italicized. 

Line 289, what is the number (12)?

Lines 317-323, please rephrase. It seems like C. rouxii does not have 16S rDNA. 

Lines 325-327, what does ANIb mean? Is it different from ANI?

Line 345, I think an "of" is missing.

Line 404, C. diphtheriae should be italicized. 

Author Response

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Author Response File: Author Response.pdf

Reviewer 3 Report

The authors have carried out a detailed synthesis work on the new species of Corynebacterium with the potential to produce diphtheria toxin.

I have missed a figure with the structure of the toxin. The authors empathized with the toxin and it is a bit hard to follow. 

Minor points:

Line 29: DNA. Currently, about 145 different species belong to this genus..

Line 38: toxin secreted by C. diphtheriae 

Line 212: line feed

Line 265/288/349/356/357/385/386: et al. (all in italic)

Line 279: C. ulcerans 

Line 312: C. diphtheriae biovar belfanti 

Line 404: C. diphtheriae 

Author Response

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Author Response File: Author Response.pdf