Next Article in Journal
ShK-Domain-Containing Protein from a Parasitic Nematode Modulates Drosophila melanogaster Immunity
Next Article in Special Issue
Study of the Genetic Expression of Antiretroviral Restriction Factors and Acute Phase Proteins in Cattle Infected with Bovine Leukemia Virus
Previous Article in Journal
Global Prevalence of Colistin Resistance in Klebsiella pneumoniae from Bloodstream Infection: A Systematic Review and Meta-Analysis
Previous Article in Special Issue
BoLA-DRB3 Polymorphism Controls Proviral Load and Infectivity of Bovine Leukemia Virus (BLV) in Milk
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 11
Issue 10
10.3390/pathogens11101093
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Identification of BoLA Alleles Associated with BLV Proviral Load in US Beef Cows

by
Ciarra H. LaHuis
1,
Oscar J. Benitez
2,
Casey J. Droscha
3,
Sukhdeep Singh
4,
Andrew Borgman
5,
Chaelynne E. Lohr
3,
Paul C. Bartlett
6 and
Tasia M. Taxis
1,*
1
Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI 48824, USA
2
School of Veterinary Medicine, Texas Tech University, Lubbock, TX 79415, USA
3
CentralStar Cooperative, Lansing, MI 48910, USA
4
Department of Plant, Soil and Microbial Sciences, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI 48824, USA
5
Borgman Consulting Group LLC, Alma, MI 48801, USA
6
Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 488424, USA
*
Author to whom correspondence should be addressed.
Pathogens 2022, 11(10), 1093; https://doi.org/10.3390/pathogens11101093
Submission received: 16 June 2022 / Revised: 15 September 2022 / Accepted: 19 September 2022 / Published: 24 September 2022
(This article belongs to the Collection Bovine Leukemia Virus Infection)
Browse Figure
Review Reports Versions Notes

Abstract

Bovine leukemia virus (BLV) causes enzootic bovine leukosis, the most common neoplastic disease in cattle. Previous work estimates that 78% of US beef operations and 38% of US beef cattle are seropositive for BLV. Infection by BLV in a herd is an economic concern for producers as evidence suggests that it causes an increase in cost and a subsequent decrease in profit to producers. Studies investigating BLV in dairy cattle have noted disease resistance or susceptibility, measured by a proviral load (PVL) associated with specific alleles of the bovine leukocyte antigen (BoLA) DRB3 gene. This study aims to investigate the associations between BoLA DRB3 alleles and BLV PVL in beef cattle. Samples were collected from 157 Midwest beef cows. BoLA DRB3 alleles were identified and compared with BLV PVL. One BoLA DRB3 allele, *026:01, was found to be associated with high PVL in relation to the average of the sampled population. In contrast, two alleles, *033:01 and *002:01, were found to be associated with low PVL. This study provides evidence of a relationship between BoLA DRB3 alleles and BLV PVL in US beef cows.
Keywords: beef cattle; BLV; BoLA DRB3; bovine leukemia virus; disease progression; disease resistance beef cattle; BLV; BoLA DRB3; bovine leukemia virus; disease progression; disease resistance

Share and Cite

MDPI and ACS Style

LaHuis, C.H.; Benitez, O.J.; Droscha, C.J.; Singh, S.; Borgman, A.; Lohr, C.E.; Bartlett, P.C.; Taxis, T.M. Identification of BoLA Alleles Associated with BLV Proviral Load in US Beef Cows. Pathogens 2022, 11, 1093. https://doi.org/10.3390/pathogens11101093

AMA Style

LaHuis CH, Benitez OJ, Droscha CJ, Singh S, Borgman A, Lohr CE, Bartlett PC, Taxis TM. Identification of BoLA Alleles Associated with BLV Proviral Load in US Beef Cows. Pathogens. 2022; 11(10):1093. https://doi.org/10.3390/pathogens11101093

Chicago/Turabian Style

LaHuis, Ciarra H., Oscar J. Benitez, Casey J. Droscha, Sukhdeep Singh, Andrew Borgman, Chaelynne E. Lohr, Paul C. Bartlett, and Tasia M. Taxis. 2022. "Identification of BoLA Alleles Associated with BLV Proviral Load in US Beef Cows" Pathogens 11, no. 10: 1093. https://doi.org/10.3390/pathogens11101093

APA Style

LaHuis, C. H., Benitez, O. J., Droscha, C. J., Singh, S., Borgman, A., Lohr, C. E., Bartlett, P. C., & Taxis, T. M. (2022). Identification of BoLA Alleles Associated with BLV Proviral Load in US Beef Cows. Pathogens, 11(10), 1093. https://doi.org/10.3390/pathogens11101093

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop