Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection
Abstract
:1. Introduction
2. The Generation of Succinate in the Airway Provides a Preferred Substrate for P. aeruginosa Proliferation
3. Excess Succinate Release Is a Consequence of CFTR-PTEN Complex Dysfunction
4. Succinate and the Production of Reactive Oxygen Species in the CF Airway
5. P. aeruginosa Induces and Assimilates Host Itaconate to Cause Long-Term Disease
6. P. aeruginosa Adaptation to Airway Metabolites and the Formation of Biofilm
7. P. aeruginosa Strains from Chronically Infected CF Subjects Exhibit Adaptation to Host Immunometabolism
8. Model Systems in CF and P. aeruginosa Pneumonia
9. Targeting P. aeruginosa Metabolism as a Therapeutic Strategy
Author Contributions
Funding
Conflicts of Interest
References
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Riquelme, S.A.; Prince, A. Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection. Pathogens 2021, 10, 957. https://doi.org/10.3390/pathogens10080957
Riquelme SA, Prince A. Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection. Pathogens. 2021; 10(8):957. https://doi.org/10.3390/pathogens10080957
Chicago/Turabian StyleRiquelme, Sebastián A., and Alice Prince. 2021. "Pseudomonas aeruginosa Consumption of Airway Metabolites Promotes Lung Infection" Pathogens 10, no. 8: 957. https://doi.org/10.3390/pathogens10080957