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Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2

1
Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
2
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34518, Egypt
3
Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
4
Radiation Biology Department, Atomic Energy Authority, Cairo 13759, Egypt
5
Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas, Houston, TX 77030, USA
6
Human Link, Jewellery & Gemplex, Dubai 48800, United Arab Emirates
*
Authors to whom correspondence should be addressed.
Equally contributed as first author.
Academic Editors: David J. Allen and Sonia Zuñiga
Pathogens 2021, 10(6), 758; https://doi.org/10.3390/pathogens10060758
Received: 24 March 2021 / Revised: 7 June 2021 / Accepted: 10 June 2021 / Published: 15 June 2021
(This article belongs to the Section Emerging Pathogens)
Until now, there has been no direct evidence of the effectiveness of repurposed FDA-approved drugs against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections. Although curcumin, hesperidin, and quercetin have broad spectra of pharmacological properties, their antiviral activities against SARS-CoV-2 remain unclear. Our study aimed to assess the in vitro antiviral activities of curcumin, hesperidin, and quercetin against SARS-CoV-2 compared to hydroxychloroquine and determine their mode of action. In Vero E6 cells, these compounds significantly inhibited virus replication, mainly as virucidal agents primarily indicating their potential activity at the early stage of viral infection. To investigate the mechanism of action of the tested compounds, molecular docking studies were carried out against both SARS-CoV-2 spike (S) and main protease (Mpro) receptors. Collectively, the obtained in silico and in vitro findings suggest that the compounds could be promising SARS-CoV-2 Mpro inhibitors. We recommend further preclinical and clinical studies on the studied compounds to find a potential therapeutic targeting COVID-19 in the near future. View Full-Text
Keywords: SARS-CoV-2; COVID-19; antiviral; curcumin; hesperidin; quercetin; molecular docking SARS-CoV-2; COVID-19; antiviral; curcumin; hesperidin; quercetin; molecular docking
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MDPI and ACS Style

Kandeil, A.; Mostafa, A.; Kutkat, O.; Moatasim, Y.; Al-Karmalawy, A.A.; Rashad, A.A.; Kayed, A.E.; Kayed, A.E.; El-Shesheny, R.; Kayali, G.; Ali, M.A. Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2. Pathogens 2021, 10, 758. https://doi.org/10.3390/pathogens10060758

AMA Style

Kandeil A, Mostafa A, Kutkat O, Moatasim Y, Al-Karmalawy AA, Rashad AA, Kayed AE, Kayed AE, El-Shesheny R, Kayali G, Ali MA. Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2. Pathogens. 2021; 10(6):758. https://doi.org/10.3390/pathogens10060758

Chicago/Turabian Style

Kandeil, Ahmed, Ahmed Mostafa, Omnia Kutkat, Yassmin Moatasim, Ahmed A. Al-Karmalawy, Adel A. Rashad, Ahmed E. Kayed, Azza E. Kayed, Rabeh El-Shesheny, Ghazi Kayali, and Mohamed A. Ali. 2021. "Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2" Pathogens 10, no. 6: 758. https://doi.org/10.3390/pathogens10060758

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