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Pathogens
Volume 10
Issue 4
10.3390/pathogens10040475
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Communication

Hybrid Atypical Enteropathogenic and Extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 Strain: A Draft Genome

by
Danielle D. Munhoz
1,*,
Fernanda F. Santos
2,†,
Thais Mitsunari
1,
Paulo A. Schüroff
1,
Waldir P. Elias
1,
Eneas Carvalho
1 and
Roxane M. F. Piazza
1,*
1
Laboratório de Bacteriologia, Instituto Butantan, São Paulo 05503-900, Brazil
2
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil
*
Authors to whom correspondence should be addressed.
†
Present address: Laboratório Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Pathogens 2021, 10(4), 475; https://doi.org/10.3390/pathogens10040475
Submission received: 24 February 2021 / Revised: 7 April 2021 / Accepted: 9 April 2021 / Published: 14 April 2021
(This article belongs to the Special Issue Escherichia coli Infections in Humans and Animals)
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Abstract

Diarrheagenic Escherichia coli is the major bacterial etiological agent of severe diarrhea and a major concern of public health. These pathogens have acquired genetic characteristics from other pathotypes, leading to unusual and singular genetic combinations, known as hybrid strains and may be more virulent due to a set of virulence factors from more than one pathotype. One of the possible combinations is with extraintestinal E. coli (ExPEC), a leading cause of urinary tract infection, often lethal after entering the bloodstream and atypical enteropathogenic E. coli (aEPEC), responsible for death of thousands of people every year, mainly children under five years old. Here we report the draft genome of a strain originally classified as aEPEC (BA1250) isolated from feces of a child with acute diarrhea. Phylogenetic analysis indicates that BA1250 genome content is genetically closer to E. coli strains that cause extraintestinal infections, other than intestinal infections. A deeper analysis showed that in fact this is a hybrid strain, due to the presence of a set of genes typically characteristic of ExPEC. These genomic findings expand our knowledge about aEPEC heterogeneity allowing further studies concerning E. coli pathogenicity and may be a source for future comparative studies, virulence characteristics, and evolutionary biology.
Keywords: E. coli; diarrhea; aEPEC; genome evolution; extraintestinal pathogen E. coli; diarrhea; aEPEC; genome evolution; extraintestinal pathogen

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MDPI and ACS Style

Munhoz, D.D.; Santos, F.F.; Mitsunari, T.; Schüroff, P.A.; Elias, W.P.; Carvalho, E.; Piazza, R.M.F. Hybrid Atypical Enteropathogenic and Extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 Strain: A Draft Genome. Pathogens 2021, 10, 475. https://doi.org/10.3390/pathogens10040475

AMA Style

Munhoz DD, Santos FF, Mitsunari T, Schüroff PA, Elias WP, Carvalho E, Piazza RMF. Hybrid Atypical Enteropathogenic and Extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 Strain: A Draft Genome. Pathogens. 2021; 10(4):475. https://doi.org/10.3390/pathogens10040475

Chicago/Turabian Style

Munhoz, Danielle D., Fernanda F. Santos, Thais Mitsunari, Paulo A. Schüroff, Waldir P. Elias, Eneas Carvalho, and Roxane M. F. Piazza. 2021. "Hybrid Atypical Enteropathogenic and Extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 Strain: A Draft Genome" Pathogens 10, no. 4: 475. https://doi.org/10.3390/pathogens10040475

APA Style

Munhoz, D. D., Santos, F. F., Mitsunari, T., Schüroff, P. A., Elias, W. P., Carvalho, E., & Piazza, R. M. F. (2021). Hybrid Atypical Enteropathogenic and Extraintestinal Escherichia coli (aEPEC/ExPEC) BA1250 Strain: A Draft Genome. Pathogens, 10(4), 475. https://doi.org/10.3390/pathogens10040475

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