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Open AccessPerspective

Precision Medicine and Exercise Therapy in Duchenne Muscular Dystrophy

1
Laboratory of Muscle and Translational Therapeutics, Department of Physical Therapy, Duquesne University, Pittsburgh, PA 15228, USA
2
McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15228, USA
Sports 2019, 7(3), 64; https://doi.org/10.3390/sports7030064
Received: 25 October 2018 / Revised: 25 February 2019 / Accepted: 5 March 2019 / Published: 15 March 2019
Precision medicine is being discussed and incorporated at all levels of health care and disease prevention, management, and treatment. Key components include new taxonomies of disease classification, the measurement and incorporation of genetics and “omics” data, biomarkers, and health care professionals who can optimize this information for a precision approach to treatment. The study and treatment of Duchenne Muscular Dystrophy is making rapid advances in these areas in addition to rapid advances in new gene and cell-based therapies. New therapies will increase the variability in disease severity, furthering a need for a precision-based approach. An area of therapy that is rarely considered in this approach is how the physiology of muscle contractions will interact with these therapies and a precision approach. As muscle pathology improves, physical activity levels will increase, which will likely be very beneficial to some patients but likely not to all. Physical activity is likely to synergistically improve these therapies and can be used to enhance muscle health and quality of life after these therapies are delivered using the tools of precision medicine. View Full-Text
Keywords: exercise; dystrophy; SNP; muscle contraction; biomarkers; gene therapy; precision medicine; precision exercise; therapy exercise; dystrophy; SNP; muscle contraction; biomarkers; gene therapy; precision medicine; precision exercise; therapy
MDPI and ACS Style

Kostek, M. Precision Medicine and Exercise Therapy in Duchenne Muscular Dystrophy. Sports 2019, 7, 64.

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