Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance
Abstract
:1. Background—Behavioral Epigenetics
2. Epigenetic Regulation Triggered by Environmental Enrichments
2.1. DNA Methylation
2.2. Histone Modification
2.3. Noncoding RNAs
3. Behavioral Epigenetic Inheritance Mechanisms
3.1. Germline-Mediated Epigenetic Inheritance
3.2. Integration between Germline and Somatic Cells in Epigenetic Inheritance
4. Considerations in the Establishment of Epigenetic Transgenerational Inheritance
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
HPA | Hypothalamic-pituitary-adrenal |
References
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Species | Inducing Conditions | Acquired Traits | Locus | Transmission Stability | Epigenetic Marks | Profiling Methods | References |
---|---|---|---|---|---|---|---|
Human | Childhood abuse (sexual contact, severe physical abuse, negligence) | Decreased expression of the glucocorticoid receptor 1F variant | NR3C1 promoter 1F | F1 | DNA methylation | Sodium bisulfite sequencing | McGowan et al., 2009 [7] |
Mouse | Chronic stress (immobilization) | Alteration HPA axis that trigger long-term stress response | NR3C1 promoter 17 | F1 | DNA methylation | Pyrosequencing | Witzmann et al., 2012 [17] |
Mouse | Unpredictable maternal separation | Depressive-like behavior | MeCP2, CB1, CRFR2 | F1-F3 | DNA methylation | Pyrosequencing | Franklin et al., 2010 [8] |
Mouse | Chronic social defeat stress–social avoidance | Depressive-like behavior: less interactive in the population | BDNF gene | F1 | Post translation histone modifications | ChIP assays | Tsankova et al., 2006 [18] |
Mouse | Paternal chronic stress exposure | Increased miRNA variants expression: HPA stress axis dysregulation | CRFr1, POMC, Mc2r, 11βHSD-1 | F1 | miRNAs | TaqMan Array microRNA | Rodgers et al., 2013 [19] |
Rat | Adverse maternal care | Aberrant BDNF DNA methylation result in atypical adverse maternal behavior | BDNF gene | F1-F2 | DNA methylation | MeDIP-seq | Roth et al., 2009 [20] |
Mouse | Parental olfactory experience | Hypomethylation: Increased behavioral sensitivity to acetophenone (odor) | Olfr151 gene | F1-F2 | DNA methylation | Illumina sequencer | Dias & Ressler, 2014 [21] |
Mouse | Prenatal stress exposure | Dysmasculinization | F1-F2 | miRNAs | Morgan & Bale, 2011 [22] | ||
Mouse | MSUS (unpredictable maternal separation & stress) | Altered metabolic response | F1-F3 | miRNAs & piRNAs | Gapp et al., 2014 [23] | ||
Rat | Prenatal chronic restraint stress | Dysregulation of offspring gene expression and impact on offspring neurodevelopment system | HSD11B2 | F1 | DNA methylation | Pyrosequencing | Peña et al.,2012 [24] |
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Pang, Y.-Y.; Lu, R.J.-H.; Chen, P.-Y. Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance. Epigenomes 2019, 3, 18. https://doi.org/10.3390/epigenomes3030018
Pang Y-Y, Lu RJ-H, Chen P-Y. Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance. Epigenomes. 2019; 3(3):18. https://doi.org/10.3390/epigenomes3030018
Chicago/Turabian StylePang, You-Yuan, Rita Jui-Hsien Lu, and Pao-Yang Chen. 2019. "Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance" Epigenomes 3, no. 3: 18. https://doi.org/10.3390/epigenomes3030018
APA StylePang, Y.-Y., Lu, R. J.-H., & Chen, P.-Y. (2019). Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance. Epigenomes, 3(3), 18. https://doi.org/10.3390/epigenomes3030018