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Epigenomes 2017, 1(3), 20; https://doi.org/10.3390/epigenomes1030020

Genome-Wide Epigenetic Studies in Chicken: A Review

1
URA, INRA, 37380 Nouzilly, France
2
GenPhySE, Université de Toulouse, INRA, INPT, ENVT, 31326 Castanet Tolosan, France
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Muller Fabbri
Received: 26 September 2017 / Revised: 17 November 2017 / Accepted: 21 November 2017 / Published: 23 November 2017
Full-Text   |   PDF [970 KB, uploaded 23 November 2017]   |  

Abstract

Over the years, farmed birds have been selected on various performance traits mainly through genetic selection. However, many studies have shown that genetics may not be the sole contributor to phenotypic plasticity. Gene expression programs can be influenced by environmentally induced epigenetic changes that may alter the phenotypes of the developing animals. Recently, high-throughput sequencing techniques became sufficiently affordable thanks to technological advances to study whole epigenetic landscapes in model plants and animals. In birds, a growing number of studies recently took advantage of these techniques to gain insights into the epigenetic mechanisms of gene regulation in processes such as immunity or environmental adaptation. Here, we review the current gain of knowledge on the chicken epigenome made possible by recent advances in high-throughput sequencing techniques by focusing on the two most studied epigenetic modifications, DNA methylation and histone post-translational modifications. We discuss and provide insights about designing and performing analyses to further explore avian epigenomes. A better understanding of the molecular mechanisms underlying the epigenetic regulation of gene expression in relation to bird phenotypes may provide new knowledge and markers that should undoubtedly contribute to a sustainable poultry production. View Full-Text
Keywords: high-throughput sequencing; epigenomics; poultry; bird; chicken; DNA methylation; histone post-translational modifications high-throughput sequencing; epigenomics; poultry; bird; chicken; DNA methylation; histone post-translational modifications
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David, S.-A.; Mersch, M.; Foissac, S.; Collin, A.; Pitel, F.; Coustham, V. Genome-Wide Epigenetic Studies in Chicken: A Review. Epigenomes 2017, 1, 20.

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