Implementation of Polygenic Risk Stratification and Genomic Counseling in Colombia: An Embedded Mixed-Methods Study
Abstract
1. Introduction
2. Materials and Methods
2.1. Setting: “Soy Generación” Study
Variables and Data Collection
2.2. Polygenic Risk Score Development and Classification
2.3. Genomic Counseling Model
2.3.1. Understanding Phase
2.3.2. Design Phase
2.3.3. Implementation Phase
2.4. Clinical Follow-Up and Patient Experience
2.4.1. Clinical Follow-Up
2.4.2. Patient Experience
2.4.3. Statistical Analysis
3. Results
3.1. Implementation Outcomes
3.2. Clinical Follow-Up and Patient Experience
3.2.1. Communication Effectiveness
“I have two challenges: letting go of paradigms and many thoughts. When I bring an important piece of genetic health information from my parents, it acts as a warning signal—something to pay attention to. It’s a chance to prioritize which health conditions I need to address first. Being part of this process, which has the potential to change the lives of many women, feels like a beautiful gift. It’s helped me change my physical activity routine. While at times it brings anxiety and less pleasant emotions, it also offers the opportunity to think differently, to face fears and anxieties, and to see these as part of the process.”Participant 20
“It’s been excellent—very good and reassuring. For context, someone in my family passed away from breast cancer that metastasized. We lived through the entire process without any improvement, and it left a permanent mark on me. When I was called to participate, I felt a little scared and thought, ‘Oh my God, could something bad happen?’ But everything turned out to be a blessing. Being part of this model has made me more conscious. It became a personal challenge to make changes. With the ‘Vive Más’ platform, I started moving more, dancing, and seeking change. Today, I feel at peace after this test.”Participant 2
3.2.2. Patient Support
“When I was invited to be part of the model, I thought, ‘Why me? Did they find something?’ But when they explained it to me, I realized what a gift the company was giving us.”Participant 30
“The clarity of the explanations was remarkable. They told us, ‘This process is to identify the probability of risk.’ The specialized exams and the warmth of everyone involved in the process made me feel valued. On the day of the tests, I felt like a queen—it has such an integral approach.”Participant 9
“I feel reassured, knowing this is about prevention and care. The genetic percentage and the sporadic percentage were explained so clearly. I feel accompanied by experts who guide me and show progress every step of the way.”Participant 5
3.2.3. Relevance of Recommendations
3.2.4. Accessibility of Counseling
“I felt the phone session was helpful, but a video call would have felt more connected”Participant 10
“Telemedicine made it easy to focus on my health without worrying about logistics”.Participant 3
3.2.5. Overall Satisfaction
“The whole process was seamless; from the moment I was invited to join until the final step. It felt very well-coordinated”.Participant 18
“I felt like I was really part of the process and that I had all the information I needed to take care of myself”.Participant 22
“It gave me the tools to take proactive steps, knowing both my genetic risk and what I can do about it”.Participant 40
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
PRS | Polygenic risk score |
LMICs | Low-and middle-income countries |
NGS | Next-generation sequencing |
GCIRS | Genetic Counseling Intervention Reporting Standards. |
WISDOM | Women Informed to Screen Depending on Measures of Risk |
MyPeBS | My Personal Breast Screening |
CRF | Digital Case Report form |
BIRADS | Breast Imaging Reporting and Data System |
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Characteristics | Control, N = 1487 1 | Case, N = 510 1 |
---|---|---|
Age | 69.7 (67–71) | 55 (49–61) |
Rural or urban residence | ||
Rural | 107 (7.2%) | 39 (7.6%) |
Urban | 1380 (93%) | 471 (92%) |
Socioeconomic level | ||
1 | 53 (3.6%) | 29 (5.7%) |
2 | 269 (18%) | 138 (27%) |
3 | 490 (33%) | 232 (45%) |
5 | 357 (24%) | 71 (14%) |
5 | 233 (16%) | 29 (5.7%) |
6 | 85 (5.7%) | 11 (2.2%) |
Clinical risk classification | ||
High (>1.9) | 144 (9.7%) | 44 (8.6%) |
Low (<1) | 688 (46%) | 203 (40%) |
Moderate (1.4–1.9) | 189 (13%) | 91 (18%) |
Referent (1–1.4) | 466 (31%) | 172 (34%) |
Breast cancer diagnosis | ||
Biopsy | 3 (0.6%) | - |
Breast echography | 80 (17%) | - |
Mammography | 315 (67%) | - |
Tomosynthesis mammography | 73 (15%) | - |
Characteristics | High (1.9), N = 144 1 | Low (<1) N = 688 1 | Moderate (1.4–1.9) N = 189 1 | Referent (1–1.4) N = 466 1 | p-Value 2 |
---|---|---|---|---|---|
Age | 69.9 (3.4) | 69.7 (3.5) | 69.4 (3.3) | 69.8 (3.6) | 0.4 |
Rural or Urban residence | 0.8 | ||||
Rural | 8 (5.6%) | 53 (7.7%) | 15 (7.9%) | 31 (6.7%) | |
Urban | 136 (94%) | 635 (92%) | 174 (92%) | 435 (93%) | |
Socioeconomic level | 0.9 | ||||
1 | 3 (2.1%) | 26 (3.8%) | 5 (2.6%) | 19 (4.1%) | |
2 | 23 (16%) | 125 (18%) | 35 (19%) | 86 (18%) | |
3 | 48 (33%) | 228 (33%) | 60 (32%) | 154 (33%) | |
4 | 33 (23%) | 157 (23%) | 56 (30%) | 111 (24%) | |
5 | 29 (20%) | 110 (16%) | 25 (13%) | 69 (15%) | |
6 | 8 (5.6%) | 42 (6.1%) | 8 (4.2%) | 27 (5.8%) |
Variable | Case, N = 457 1 | Control, N = 1283 1 | p-Value 2 |
---|---|---|---|
Protective factors | |||
Diet * | 431 (94%) | 1188 (93%) | 0.2 |
Physical activity ** | 257 (56%) | 900 (70%) | <0.001 |
Risk factors | |||
Diet with fats | 328 (72%) | 904 (70%) | 0.6 |
Active smoking | 11 (2.4%) | 44 (3.4%) | 0.3 |
Former smoker | 58 (13%) | 318 (26%) | <0.001 |
Alcohol | 76 (17%) | 171 (13%) | 0.082 |
Variable | OR | p-Value | IC |
---|---|---|---|
Protective factors | |||
Diet | 1.326 | 0.217 | (0.86, 2.113) |
Physical Activity | 0.547 | 0.000 | (0.439, 0.682) |
Risk Factors | |||
Diet with Fats | 1.066 | 0.596 | (0.843, 1.353) |
Active Smoking | 0.695 | 0.286 | (0.338, 1.308) |
Former smoker | 0.435 | 0.000 | (0.318, 0.585) |
Alcohol | 1.297 | 0.083 | (0.963, 1.735) |
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Buitrago, C.A.; Naranjo Vanegas, M.; Velasco, H.M.; Cardona, D.S.; Valencia-Arango, J.P.; Franco, S.L.; Torres, L.M.; Cañaveral, J.; Silgado, D.P.; López Cáceres, A. Implementation of Polygenic Risk Stratification and Genomic Counseling in Colombia: An Embedded Mixed-Methods Study. J. Pers. Med. 2025, 15, 335. https://doi.org/10.3390/jpm15080335
Buitrago CA, Naranjo Vanegas M, Velasco HM, Cardona DS, Valencia-Arango JP, Franco SL, Torres LM, Cañaveral J, Silgado DP, López Cáceres A. Implementation of Polygenic Risk Stratification and Genomic Counseling in Colombia: An Embedded Mixed-Methods Study. Journal of Personalized Medicine. 2025; 15(8):335. https://doi.org/10.3390/jpm15080335
Chicago/Turabian StyleBuitrago, Cesar Augusto, Melisa Naranjo Vanegas, Harvy Mauricio Velasco, Danny Styvens Cardona, Juan Pablo Valencia-Arango, Sofia Lorena Franco, Lina María Torres, Johana Cañaveral, Diana Patricia Silgado, and Andrea López Cáceres. 2025. "Implementation of Polygenic Risk Stratification and Genomic Counseling in Colombia: An Embedded Mixed-Methods Study" Journal of Personalized Medicine 15, no. 8: 335. https://doi.org/10.3390/jpm15080335
APA StyleBuitrago, C. A., Naranjo Vanegas, M., Velasco, H. M., Cardona, D. S., Valencia-Arango, J. P., Franco, S. L., Torres, L. M., Cañaveral, J., Silgado, D. P., & López Cáceres, A. (2025). Implementation of Polygenic Risk Stratification and Genomic Counseling in Colombia: An Embedded Mixed-Methods Study. Journal of Personalized Medicine, 15(8), 335. https://doi.org/10.3390/jpm15080335