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Article

Association between Cardiovascular Risk Assessment by SCORE2 and Diverticulosis: A Cross-Sectional Analysis

by
Andreas Völkerer
1,*,
Sarah Wernly
1,
Georg Semmler
2,
Maria Flamm
3,
Konrad Radzikowski
1,
Leonora Datz
1,
Nikolaus Götz
4,
Hannah Hofer
1,
Elmar Aigner
5,
Christian Datz
1,† and
Bernhard Wernly
1,3,†
1
Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria
2
Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, 1090 Vienna, Austria
3
Institute of General Practice, Family Medicine and Preventive Medicine, Center for Public Health and Healthcare Research Paracelsus Medical University, 5020 Salzburg, Austria
4
Department of Internal Medicine, General Hospital St. Vinzenz Zams, 6511 Zams, Austria
5
Clinic I for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2024, 14(8), 862; https://doi.org/10.3390/jpm14080862
Submission received: 16 July 2024 / Revised: 11 August 2024 / Accepted: 13 August 2024 / Published: 14 August 2024
(This article belongs to the Section Epidemiology)
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Abstract

Background: The aim of this retrospective observational study was to examine the relationship between SCORE2 and the occurrence of colonic diverticula in a screening population without cardiovascular or gastrointestinal symptoms. SCORE2, recognized and supported by the European Society of Cardiology for cardiovascular risk assessment, served as the primary metric for the analysis in this investigation. Methods: We studied 3935 asymptomatic individuals undergoing screening colonoscopy. SCORE2 was calculated for each participant and categorized into three groups based on the following projected 10-year cardiovascular disease risk: SCORE2 0–4.9%, SCORE2 5–9.9%, and SCORE2 ≥ 10%. Logistic regression was used to assess the relationship between SCORE2 and diverticulosis. Results: SCORE2 was associated with the presence of diverticulosis (OR 1.09, 95%CI 1.07–1.10; p < 0.001) in univariable logistic regression, translating into an RR of 1.07 per unit increase. The association persisted after multivariable adjusting for metabolic syndrome (aOR 1.08; 95%CI 1.06–1.10; p < 0.001). Patients with high cardiovascular risk had higher rates of diverticulosis compared to those with lower risk: high risk (OR 2.00, 95%CI 1.71–2.33; p < 0.001); very high risk (OR 2.53, 95%CI 2.10–3.05; p < 0.001). This association remained after adjusting for metabolic syndrome: high risk (aOR 1.86, 95%CI 1.59–2.18; p < 0.001); very high risk (aOR 2.27, 95%CI 1.88–2.75; p < 0.001). Conclusions: A higher SCORE2 was found to be a suitable screening parameter for diverticular disease. This suggests a potential link between cardiovascular risk factors and colon diverticula development, warranting further research on whether optimizing cardiovascular risk factors could positively influence diverticular disease.
Keywords: diverticulosis; SCORE2; metabolic syndrome; cardiovascular risk diverticulosis; SCORE2; metabolic syndrome; cardiovascular risk

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MDPI and ACS Style

Völkerer, A.; Wernly, S.; Semmler, G.; Flamm, M.; Radzikowski, K.; Datz, L.; Götz, N.; Hofer, H.; Aigner, E.; Datz, C.; et al. Association between Cardiovascular Risk Assessment by SCORE2 and Diverticulosis: A Cross-Sectional Analysis. J. Pers. Med. 2024, 14, 862. https://doi.org/10.3390/jpm14080862

AMA Style

Völkerer A, Wernly S, Semmler G, Flamm M, Radzikowski K, Datz L, Götz N, Hofer H, Aigner E, Datz C, et al. Association between Cardiovascular Risk Assessment by SCORE2 and Diverticulosis: A Cross-Sectional Analysis. Journal of Personalized Medicine. 2024; 14(8):862. https://doi.org/10.3390/jpm14080862

Chicago/Turabian Style

Völkerer, Andreas, Sarah Wernly, Georg Semmler, Maria Flamm, Konrad Radzikowski, Leonora Datz, Nikolaus Götz, Hannah Hofer, Elmar Aigner, Christian Datz, and et al. 2024. "Association between Cardiovascular Risk Assessment by SCORE2 and Diverticulosis: A Cross-Sectional Analysis" Journal of Personalized Medicine 14, no. 8: 862. https://doi.org/10.3390/jpm14080862

APA Style

Völkerer, A., Wernly, S., Semmler, G., Flamm, M., Radzikowski, K., Datz, L., Götz, N., Hofer, H., Aigner, E., Datz, C., & Wernly, B. (2024). Association between Cardiovascular Risk Assessment by SCORE2 and Diverticulosis: A Cross-Sectional Analysis. Journal of Personalized Medicine, 14(8), 862. https://doi.org/10.3390/jpm14080862

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