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Volume 13
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10.3390/jpm13010006
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Case Report

Intra Uterine Insemination in Two Couples with HPV Detection by Hyaluronidase-Based Swim-up Washing: Cases Report

by
Ilaria Cosci
1,†,
Luca De Toni
2,†,
Francesca Vasoin De Prosperi
3,
Carrie Bedoni
3,
Rafael Ramirez
3,
Grazia Buonfantino
3,
Alberto Ferlin
2 and
Andrea Garolla
2,3,*
1
Veneto Institute of Oncology IOV—IRCCS, 35128 Padova, Italy
2
Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, 35128 Padova, Italy
3
Garolla Clinic—IUI Center, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Pers. Med. 2023, 13(1), 6; https://doi.org/10.3390/jpm13010006
Submission received: 30 November 2022 / Revised: 14 December 2022 / Accepted: 18 December 2022 / Published: 20 December 2022
(This article belongs to the Section Personalized Therapy and Drug Delivery)
Review Reports Versions Notes

Abstract

Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide and is associated with negative reproductive outcomes because of which it is recommended to postpone medically assisted reproduction (MAR). This raises major concerns for elder infertile couples. We showed that a hyaluronidase-based sperm washing (IALu) procedure blunted the HPV viral load in semen. Here, were report two cases of couples with long-term idiopathic infertility, ascribed to persistent semen HPV detection, finding a beneficial outcome from the use of IALu protocol applied to intra-uterine insemination (IUI). Case 1: A Caucasian couple (female aged 32, male aged 35), complained of having been attempting pregnancy for 4 years. HPV-DNA (genotypes 51 and 54) was detected on sperms. After a first unsuccessful IUI cycle attempt, using standard swim-up selection of spermatozoa, a second IUI cycle using the IALu procedure was associated with a pregnancy and a successful trimester of gestation. Case 2: A Caucasian couple (female aged 43, male aged 52) complained of having been attempting pregnancy for 3 years and showed the detection of HPV-DNA (genotype 66) on sperms. After a first unsuccessful standard IUI cycle attempt, two further IUI cycles using IALu procedure were pursued. The last cycle was associated with a pregnancy and a successful trimester of gestation. Although preliminary, the IALu procedure is a promising approach for straightforward fertility treatments in cases of recurrent HPV-DNA semen detection, avoiding critical latencies.
Keywords: virology; pregnancy; biochemistry virology; pregnancy; biochemistry

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MDPI and ACS Style

Cosci, I.; De Toni, L.; Vasoin De Prosperi, F.; Bedoni, C.; Ramirez, R.; Buonfantino, G.; Ferlin, A.; Garolla, A. Intra Uterine Insemination in Two Couples with HPV Detection by Hyaluronidase-Based Swim-up Washing: Cases Report. J. Pers. Med. 2023, 13, 6. https://doi.org/10.3390/jpm13010006

AMA Style

Cosci I, De Toni L, Vasoin De Prosperi F, Bedoni C, Ramirez R, Buonfantino G, Ferlin A, Garolla A. Intra Uterine Insemination in Two Couples with HPV Detection by Hyaluronidase-Based Swim-up Washing: Cases Report. Journal of Personalized Medicine. 2023; 13(1):6. https://doi.org/10.3390/jpm13010006

Chicago/Turabian Style

Cosci, Ilaria, Luca De Toni, Francesca Vasoin De Prosperi, Carrie Bedoni, Rafael Ramirez, Grazia Buonfantino, Alberto Ferlin, and Andrea Garolla. 2023. "Intra Uterine Insemination in Two Couples with HPV Detection by Hyaluronidase-Based Swim-up Washing: Cases Report" Journal of Personalized Medicine 13, no. 1: 6. https://doi.org/10.3390/jpm13010006

APA Style

Cosci, I., De Toni, L., Vasoin De Prosperi, F., Bedoni, C., Ramirez, R., Buonfantino, G., Ferlin, A., & Garolla, A. (2023). Intra Uterine Insemination in Two Couples with HPV Detection by Hyaluronidase-Based Swim-up Washing: Cases Report. Journal of Personalized Medicine, 13(1), 6. https://doi.org/10.3390/jpm13010006

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