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Article

Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis

by
Ulrike Förster-Ruhrmann
1,
Agnieszka J. Szczepek
2,3,*,
Greta Pierchalla
1,
Joachim W. Fluhr
4,5,
Metin Artuc
4,
Torsten Zuberbier
4,5,
Claus Bachert
6 and
Heidi Olze
1,2,*
1
Department of Otorhinolaryngology Head and Neck Surgery CVK, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany
2
Department of Otorhinolaryngology Head and Neck Surgery CCM, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany
3
Faculty of Medicine and Health Sciences, University of Zielona Gora, 65-046 Zielona Gora, Poland
4
Institute of Allergology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany
5
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, 12203 Berlin, Germany
6
Upper Airway Research Laboratory, Ghent University, 9000 Ghent, Belgium
*
Authors to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(4), 646; https://doi.org/10.3390/jpm12040646
Submission received: 18 February 2022 / Revised: 14 April 2022 / Accepted: 15 April 2022 / Published: 18 April 2022
(This article belongs to the Special Issue Personalized Medicine in Otorhinolaryngology)
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Abstract

Chronic rhinosinusitis (CRS) with (CRSwNP) or without nasal polyps (CRSsNP) is a persistent, heterogeneous inflammatory condition affecting the upper respiratory tract. The present study aimed to improve the characterization of CRS endotypes based on the chemokine and cytokine expression pattern in the CRS tissues. Concentrations of chemokines and cytokines were measured in tissues from nasal biopsies obtained from 66 CRS patients and 25 control subjects using multiplexing or single analyte technologies. Cluster analysis based on the concentration of type-1 (MCP-3/CCL7, MIP-1 α/CCL3), type-2 (IL-5, MCP-3/CCL7, MIP-1 α/CCL3, TARC/CCL17, PARC/CCL18, IP-10/CXCL10, ECP), and type-3 (IL-22) chemokines and cytokines identified six CRS endotypes (clusters). Cluster 1 (type-3) and 2 (type-1) were associated with a low prevalence of nasal polyps, Cluster 3 (type-1, -2, -3) and Cluster 4 (type-2, -3, medium IL-22) with medium, and Cluster 5 (type-2, -3, high Il-22) and Cluster 6 (type-2) with high prevalence of nasal polyps. Asthma was highly prevalent in Cluster-6. Our findings add to the existing knowledge of CRS endotypes and may be useful for the clinical decision-making process. The advancement of biologics therapy for upper respiratory tract disorders rationalizes the personalized diagnostic approach to warrant a successful treatment and monitoring of CRS.
Keywords: chronic rhinosinusitis; nasal polyps; asthma; chemokines; cytokines; endotyping chronic rhinosinusitis; nasal polyps; asthma; chemokines; cytokines; endotyping

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MDPI and ACS Style

Förster-Ruhrmann, U.; Szczepek, A.J.; Pierchalla, G.; Fluhr, J.W.; Artuc, M.; Zuberbier, T.; Bachert, C.; Olze, H. Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis. J. Pers. Med. 2022, 12, 646. https://doi.org/10.3390/jpm12040646

AMA Style

Förster-Ruhrmann U, Szczepek AJ, Pierchalla G, Fluhr JW, Artuc M, Zuberbier T, Bachert C, Olze H. Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis. Journal of Personalized Medicine. 2022; 12(4):646. https://doi.org/10.3390/jpm12040646

Chicago/Turabian Style

Förster-Ruhrmann, Ulrike, Agnieszka J. Szczepek, Greta Pierchalla, Joachim W. Fluhr, Metin Artuc, Torsten Zuberbier, Claus Bachert, and Heidi Olze. 2022. "Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis" Journal of Personalized Medicine 12, no. 4: 646. https://doi.org/10.3390/jpm12040646

APA Style

Förster-Ruhrmann, U., Szczepek, A. J., Pierchalla, G., Fluhr, J. W., Artuc, M., Zuberbier, T., Bachert, C., & Olze, H. (2022). Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis. Journal of Personalized Medicine, 12(4), 646. https://doi.org/10.3390/jpm12040646

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