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Article

The Number of Surgical Interventions and Specialists Involved in the Management of Patients with Neurofibromatosis Type I: A 25-Year Analysis

Department of Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally in this study.
Academic Editors: Andreas Arkudas and Raymund E. Horch
J. Pers. Med. 2022, 12(4), 558; https://doi.org/10.3390/jpm12040558
Received: 6 February 2022 / Revised: 24 March 2022 / Accepted: 24 March 2022 / Published: 1 April 2022
(This article belongs to the Special Issue Plastic and Reconstructive Surgery in Personalized Medicine)
Objective: In this study, we aim to present a single institution’s 25-year experience of employing a comprehensive multidisciplinary team-based surgical approach for treating patients with NF-1. Summary Background Data: All patients (n = 106) with a confirmed diagnosis of NF-1 who were treated using a multidisciplinary surgical treatment algorithm at Chang Gung Memorial Hospital between 1994 and 2019 were retrospectively enrolled. Patients were categorized into groups according to the anatomy involved (craniofacial and noncraniofacial groups) and the type of clinical presentation (plexiform and cutaneous neurofibromas groups) for comparative analysis. Methods: The number of surgical interventions and number of specialists involved in surgical care were assessed. Results: Most of the patients exhibited craniofacial involvement (69.8%) and a plexiform type of NF-1 (58.5%), as confirmed through histology. A total of 332 surgical interventions (3.1 ± 3.1 procedures per patient) were performed. The number of specialists involved in surgical care of the included patients was 11 (1.6 ± 0.8 specialists per patient). Most of the patients (62.3%) underwent two or more surgical interventions, and 40.6% of the patients received treatment from two or more specialists. No significant differences were observed between the craniofacial and noncraniofacial groups in terms of the average number of surgical interventions (3.3 ± 3.2 vs. 2.7 ± 2.7, respectively) and number of specialists involved (1.7 ± 0.9 vs. 1.4 ± 0.6). Patients with plexiform craniofacial involvement underwent a significantly higher average number of surgical interventions (4.3 ± 3.6 vs. 1.6 ± 1.1; p < 0.001) and received treatment by more specialists (1.9 ± 0.9 vs. 1.2 ± 0.5; p < 0.001) compared with those having cutaneous craniofacial involvement. Conclusions: In light of the potential benefits of employing the multidisciplinary team-based surgical approach demonstrated in this study, such an approach should be adopted to provide comprehensive individualized care to patients with NF-1. View Full-Text
Keywords: neurofibromatosis; craniofacial; surgical treatment; multidisciplinary team; plexiform neurofibroma neurofibromatosis; craniofacial; surgical treatment; multidisciplinary team; plexiform neurofibroma
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MDPI and ACS Style

Hsu, C.-K.; Denadai, R.; Chang, C.-S.; Yao, C.-F.; Chen, Y.-A.; Chou, P.-Y.; Lo, L.-J.; Chen, Y.-R. The Number of Surgical Interventions and Specialists Involved in the Management of Patients with Neurofibromatosis Type I: A 25-Year Analysis. J. Pers. Med. 2022, 12, 558. https://doi.org/10.3390/jpm12040558

AMA Style

Hsu C-K, Denadai R, Chang C-S, Yao C-F, Chen Y-A, Chou P-Y, Lo L-J, Chen Y-R. The Number of Surgical Interventions and Specialists Involved in the Management of Patients with Neurofibromatosis Type I: A 25-Year Analysis. Journal of Personalized Medicine. 2022; 12(4):558. https://doi.org/10.3390/jpm12040558

Chicago/Turabian Style

Hsu, Chih-Kai, Rafael Denadai, Chun-Shin Chang, Chuan-Fong Yao, Ying-An Chen, Pang-Yun Chou, Lun-Jou Lo, and Yu-Ray Chen. 2022. "The Number of Surgical Interventions and Specialists Involved in the Management of Patients with Neurofibromatosis Type I: A 25-Year Analysis" Journal of Personalized Medicine 12, no. 4: 558. https://doi.org/10.3390/jpm12040558

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