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Volume 12
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10.3390/jpm12030456
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Systematic Review

The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review

by
Fatemeh Hajibabaie
1,
Navid Abedpoor
2,
Nazanin Assareh
1,
Mohammad Amin Tabatabaiefar
3,4,
Laleh Shariati
5,6,* and
Ali Zarrabi
7,*
1
Department of Physiology, Medicinal Plants Research Center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81595-158, Iran
2
Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81595-158, Iran
3
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
4
Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
5
Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
6
Biosensor Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
7
Biomedical Engineering Department, Faculty of Engineering and Natural Sciences, Istinye University, Sariye, Istanbul 34396, Turkey
*
Authors to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(3), 456; https://doi.org/10.3390/jpm12030456
Submission received: 8 January 2022 / Revised: 8 March 2022 / Accepted: 9 March 2022 / Published: 14 March 2022
(This article belongs to the Special Issue MiRNA Targets in Cancer: Diagnosis, Prognosis and Treatment)
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Abstract

Dysregulated mRNA–miRNA profiles might have the prospective to be used for early diagnosis of gastrointestinal cancers, estimating survival, and predicting response to treatment. Here, a novel biomarker based on miRNAs binding to mRNAs in single nucleotide polymorphism (SNP) sites related to gastrointestinal cancers is introduced that could act as an early diagnosis. The electronic databases used for the recruiting published articles included EMBASE, SCOPUS, Web of Science, and PubMed, based on MESH keywords and PRISMA methodology. Based on the considered criteria, different experimental articles were reviewed, during which 15 studies with the desired criteria were collected. Accordingly, novel biomarkers in prediction, early prognosis, and diagnosis of gastrointestinal cancers were highlighted. Moreover, it was found that 20 SNP sites and 16 miRNAs were involved in gastrointestinal cancers, with altered expression patterns associated with clinicopathological and demographic data. The results of this systematic study revealed that SNPs could affect the binding of miRNAs in the SNP sites that might play a principal role in the progression, invasion, and susceptibility of gastrointestinal cancers. In addition, it was found that the profiles of SNPs and miRNAs could serve as a convenient approach for the prognosis and diagnosis of gastric and colorectal cancers.
Keywords: colorectal cancer; gastric cancer; miRNA; single nucleotide polymorphism; biomarkers colorectal cancer; gastric cancer; miRNA; single nucleotide polymorphism; biomarkers

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MDPI and ACS Style

Hajibabaie, F.; Abedpoor, N.; Assareh, N.; Tabatabaiefar, M.A.; Shariati, L.; Zarrabi, A. The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review. J. Pers. Med. 2022, 12, 456. https://doi.org/10.3390/jpm12030456

AMA Style

Hajibabaie F, Abedpoor N, Assareh N, Tabatabaiefar MA, Shariati L, Zarrabi A. The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review. Journal of Personalized Medicine. 2022; 12(3):456. https://doi.org/10.3390/jpm12030456

Chicago/Turabian Style

Hajibabaie, Fatemeh, Navid Abedpoor, Nazanin Assareh, Mohammad Amin Tabatabaiefar, Laleh Shariati, and Ali Zarrabi. 2022. "The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review" Journal of Personalized Medicine 12, no. 3: 456. https://doi.org/10.3390/jpm12030456

APA Style

Hajibabaie, F., Abedpoor, N., Assareh, N., Tabatabaiefar, M. A., Shariati, L., & Zarrabi, A. (2022). The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review. Journal of Personalized Medicine, 12(3), 456. https://doi.org/10.3390/jpm12030456

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