Next Article in Journal
Computational Genomics in the Era of Precision Medicine: Applications to Variant Analysis and Gene Therapy
Next Article in Special Issue
The Many Faces of Huntington’s Chorea Treatment: The Impact of Sudden Withdrawal of Tiapride after 40 Years of Use and a Systematic Review
Previous Article in Journal
Female Human Papillomavirus Infection Associated with Increased Risk of Ectopic Pregnancy: Early Evidence from Taiwan Population-Based Cohort Study
Previous Article in Special Issue
“Spazio Huntington”: Tracing the Early Motor, Cognitive and Behavioral Profiles of Kids with Proven Pediatric Huntington Disease and Expanded Mutations > 80 CAG Repeats
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JPM
Volume 12
Issue 2
10.3390/jpm12020174
jpm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington’s Disease

by
Pablo Lemercier
1,2,3,4,
Laurent Cleret de Langavant
1,2,3,4,
Jennifer Hamet Bagnou
1,2,3,4,
Katia Youssov
1,3,4,
Laurie Lemoine
1,2,3,4,
Etienne Audureau
5,
Renaud Massart
1,2,3,4 and
Anne-Catherine Bachoud-Lévi
1,2,3,4,*
1
Département d’Etudes Cognitives, Ecole Normale Supérieure, PSL University, 75005 Paris, France
2
Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biomédicale, INSERM U955, University Paris Est Créteil, 94000 Créteil, France
3
Centre National de Référence Maladie de Huntington, Service de Neurologie, Hôpital Henri Mondor-Albert Chenevier, AP-HP, 94000 Créteil, France
4
NeurATRIS, 94000 Créteil, France
5
Clinical Epidemiology and Ageing, Service de Santé Publique, Henri Mondor Hospital, AP-HP, 94000 Créteil, France
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(2), 174; https://doi.org/10.3390/jpm12020174
Submission received: 15 December 2021 / Revised: 19 January 2022 / Accepted: 25 January 2022 / Published: 27 January 2022
(This article belongs to the Special Issue The Many Faces of Huntington Disease)
Browse Figures
Review Reports Versions Notes

Abstract

Huntington’s Disease (HD) is an inherited neurodegenerative disease characterized by a combination of motor, cognitive, and behavioral disorders. The social and behavioral symptoms observed in HD patients impact their quality of life and probably explain their relational difficulties, conflicts, and social withdrawal. In this study, we described the development of the Social Relationship Self-Questionnaire (SRSQ), a self-reporting questionnaire that assesses how HD patients perceived their social relationships. The scale was proposed for 66 HD patients at an early stage of the disease, 32 PreHD patients (individuals carrying the mutant gene without motor symptoms), and 66 controls. The HD patients were included in a prospective longitudinal follow-up for an average of 1.07 years with motor, functional, cognitive, and behavioral assessments. Based on the HD patients’ answers at baseline, we identified two domains in the SRSQ. The first domain was related to social motivation and correlated with cognitive performance. The second domain was related to emotional insight and correlated with behavioral symptoms such as apathy, anxiety, and irritability. We discovered that both SRSQ domain scores at baseline predicted future motor, functional, and cognitive decline in HD.
Keywords: Huntington’s disease; social relationships; disease progression; auto-questionnaire Huntington’s disease; social relationships; disease progression; auto-questionnaire

Share and Cite

MDPI and ACS Style

Lemercier, P.; Cleret de Langavant, L.; Hamet Bagnou, J.; Youssov, K.; Lemoine, L.; Audureau, E.; Massart, R.; Bachoud-Lévi, A.-C. Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington’s Disease. J. Pers. Med. 2022, 12, 174. https://doi.org/10.3390/jpm12020174

AMA Style

Lemercier P, Cleret de Langavant L, Hamet Bagnou J, Youssov K, Lemoine L, Audureau E, Massart R, Bachoud-Lévi A-C. Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington’s Disease. Journal of Personalized Medicine. 2022; 12(2):174. https://doi.org/10.3390/jpm12020174

Chicago/Turabian Style

Lemercier, Pablo, Laurent Cleret de Langavant, Jennifer Hamet Bagnou, Katia Youssov, Laurie Lemoine, Etienne Audureau, Renaud Massart, and Anne-Catherine Bachoud-Lévi. 2022. "Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington’s Disease" Journal of Personalized Medicine 12, no. 2: 174. https://doi.org/10.3390/jpm12020174

APA Style

Lemercier, P., Cleret de Langavant, L., Hamet Bagnou, J., Youssov, K., Lemoine, L., Audureau, E., Massart, R., & Bachoud-Lévi, A.-C. (2022). Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington’s Disease. Journal of Personalized Medicine, 12(2), 174. https://doi.org/10.3390/jpm12020174

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop