Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease

Kim, Youlim; Park, Tai Sun; Kim, Tae-Hyung; Rhee, Chin Kook; Kim, Changhwan; Lee, Jae Seung; Kim, Woo Jin; Lim, Seong Yong; Park, Yong Bum; Yoo, Kwang Ha; Lee, Sang-Do; Oh, Yeon-Mok; Moon, Ji-Yong

doi:10.3390/jpm12101592

Open AccessArticle

Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease

by

Youlim Kim

^1,†

,

Tai Sun Park

^2,†

,

Tae-Hyung Kim

²

,

Chin Kook Rhee

³

,

Changhwan Kim

⁴

,

Jae Seung Lee

⁵,

Woo Jin Kim

⁶

,

Seong Yong Lim

⁷,

Yong Bum Park

⁸,

Kwang Ha Yoo

¹,

Sang-Do Lee

⁵,

Yeon-Mok Oh

⁵ and

Ji-Yong Moon

^2,*

¹

Division of Pulmonary and Allergy, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05030, Korea

²

Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Korea

³

Department of Internal Medicine, Seoul St. Mary’s Hospital, Catholic University of Korea, Seoul 06591, Korea

⁴

Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju 63241, Korea

⁵

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea

⁶

Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon 24341, Korea

⁷

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea

⁸

Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul 05355, Korea

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

J. Pers. Med. 2022, 12(10), 1592; https://doi.org/10.3390/jpm12101592

Submission received: 14 August 2022 / Revised: 21 September 2022 / Accepted: 22 September 2022 / Published: 27 September 2022

(This article belongs to the Special Issue Personalized Diagnosis and Treatment of Pulmonary Diseases)

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Abstract

Occupational exposures have been regarded as a risk factor for the development of chronic obstructive pulmonary disease (COPD). However, there is little knowledge regarding the effect of occupational exposure on the treatment outcomes of COPD. Therefore, the aim of this study was to evaluate the question of whether occupational exposure can have a potential impact on COPD outcomes. Methods: Information regarding self-reported occupational exposure for 312 patients with COPD from the Korean Obstructive Lung Disease (KOLD) Cohort were included. A comparison of the rate of acute exacerbation, annual lung function change, and quality of life according to the presence or absence of occupational exposure was performed. Results: Seventy-six patients (24.4%) had experienced occupational exposure; chemical materials were most common. At enrollment, a higher COPD-specific version of the St. George Respiratory Questionnaire total score (39.7 ± 18.8 vs. 33.1 ± 17.6, p = 0.005) and a higher exacerbation history in the past year (30.3% vs. 17.5%, p = 0.017) were observed for patients with occupational exposure compared to those without occupational exposure. Furthermore, in the follow-up period, after adjusting for potential confounders, a higher frequency of acute exacerbation (odd ratio, 1.418; 95% confidence interval, 1.027–1.956; p = 0.033) and a more rapid decline in forced expiratory volume in 1 s (p = 0.009) was observed for COPD patients with occupational exposure compared to those without occupational exposure. Conclusions: In the KOLD cohort, worse outcomes in terms of exacerbation rate and change in lung function were observed for COPD patients with occupational exposure compared to those without occupational exposure. These findings suggest that occupational exposure not only is a risk factor for COPD but also might have a prognostic impact on COPD.

Keywords: occupational exposure; chronic obstructive pulmonary disease; acute exacerbation; lung function

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MDPI and ACS Style

Kim, Y.; Park, T.S.; Kim, T.-H.; Rhee, C.K.; Kim, C.; Lee, J.S.; Kim, W.J.; Lim, S.Y.; Park, Y.B.; Yoo, K.H.; et al. Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease. J. Pers. Med. 2022, 12, 1592. https://doi.org/10.3390/jpm12101592

AMA Style

Kim Y, Park TS, Kim T-H, Rhee CK, Kim C, Lee JS, Kim WJ, Lim SY, Park YB, Yoo KH, et al. Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease. Journal of Personalized Medicine. 2022; 12(10):1592. https://doi.org/10.3390/jpm12101592

Chicago/Turabian Style

Kim, Youlim, Tai Sun Park, Tae-Hyung Kim, Chin Kook Rhee, Changhwan Kim, Jae Seung Lee, Woo Jin Kim, Seong Yong Lim, Yong Bum Park, Kwang Ha Yoo, and et al. 2022. "Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease" Journal of Personalized Medicine 12, no. 10: 1592. https://doi.org/10.3390/jpm12101592

APA Style

Kim, Y., Park, T. S., Kim, T.-H., Rhee, C. K., Kim, C., Lee, J. S., Kim, W. J., Lim, S. Y., Park, Y. B., Yoo, K. H., Lee, S.-D., Oh, Y.-M., & Moon, J.-Y. (2022). Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease. Journal of Personalized Medicine, 12(10), 1592. https://doi.org/10.3390/jpm12101592

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