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Review

Patient-Reported Outcomes following Genetic Testing for Familial Hypercholesterolemia, Breast and Ovarian Cancer Syndrome, and Lynch Syndrome: A Systematic Review

1
Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA
2
Duke-Margolis Center for Health Policy, Duke University, Washington, DC 20004, USA
3
Tanner Health System, Carrollton, GA 30117, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Pierluigi Maria Rinaldi
J. Pers. Med. 2021, 11(9), 850; https://doi.org/10.3390/jpm11090850
Received: 20 July 2021 / Revised: 23 August 2021 / Accepted: 25 August 2021 / Published: 27 August 2021
(This article belongs to the Special Issue Precision Medicine in Clinical Practice)
Background: Patient-reported outcomes (PROs) and PRO measures (PROMs) are real-world evidence that can help capture patient experiences and perspectives regarding a clinical intervention such as genetic testing. Objective: To identify and capture methods and qualitative PRO themes among studies reporting PROs following genetic testing for FH, breast and ovarian cancer syndrome, and Lynch syndrome. Methods: A systematic review was conducted via PubMed/MEDLINE, EMBASE, and Yale University’s TRIP Medical Databases on articles published by April 2021. Results: We identified 24 studies published between 1996 and 2021 representing 4279 participants that reported PROs following genetic testing for FH, breast and ovarian cancer syndrome, and Lynch syndrome. Studies collected and reported PROs from validated PROM instruments (n = 12; 50%), validated surveys (n = 7; 26%), and interviews (n = 10; 42%). PRO themes ranged across all collection methods (e.g., psychological, knowledge, coping and satisfaction, concern about stigma/discrimination, etc.). Conclusions: Important gaps identified include (1) most studies (n = 18; 75%) reported PROs following genetic testing for breast and ovarian cancer, and (2) populations reporting PROs overall were largely of White/Caucasian/Northern European/Anglo-Saxon descent. We offer recommendations and describe real-world implications for the field moving forward. View Full-Text
Keywords: patient-reported outcomes; genetic testing; familial hypercholesterolemia; breast and ovarian cancer syndrome; Lynch syndrome; genomics; germline testing patient-reported outcomes; genetic testing; familial hypercholesterolemia; breast and ovarian cancer syndrome; Lynch syndrome; genomics; germline testing
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MDPI and ACS Style

Hendricks-Sturrup, R.M.; Joseph, L.; Lu, C.Y. Patient-Reported Outcomes following Genetic Testing for Familial Hypercholesterolemia, Breast and Ovarian Cancer Syndrome, and Lynch Syndrome: A Systematic Review. J. Pers. Med. 2021, 11, 850. https://doi.org/10.3390/jpm11090850

AMA Style

Hendricks-Sturrup RM, Joseph L, Lu CY. Patient-Reported Outcomes following Genetic Testing for Familial Hypercholesterolemia, Breast and Ovarian Cancer Syndrome, and Lynch Syndrome: A Systematic Review. Journal of Personalized Medicine. 2021; 11(9):850. https://doi.org/10.3390/jpm11090850

Chicago/Turabian Style

Hendricks-Sturrup, Rachele M., Lucson Joseph, and Christine Y. Lu. 2021. "Patient-Reported Outcomes following Genetic Testing for Familial Hypercholesterolemia, Breast and Ovarian Cancer Syndrome, and Lynch Syndrome: A Systematic Review" Journal of Personalized Medicine 11, no. 9: 850. https://doi.org/10.3390/jpm11090850

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