Comparison of Hemodynamic Visualization in Cerebral Arteries: Can Magnetic Resonance Imaging Replace Computational Fluid Dynamics?

Ngo, Minh Tri; Lee, Ui Yun; Ha, Hojin; Jin, Ning; Chung, Gyung Ho; Kwak, Yeong Gon; Jung, Jinmu; Kwak, Hyo Sung

doi:10.3390/jpm11040253

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Comparison of Hemodynamic Visualization in Cerebral Arteries: Can Magnetic Resonance Imaging Replace Computational Fluid Dynamics?

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Department of Radiology and Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeon-ju 54907, Korea

Division of Mechanical Design Engineering, Jeonbuk National University, Jeon-ju 54896, Korea

Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 24341, Korea

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Siemens Medical Solutions USA, Inc., Chicago, IL 60089, USA

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Hemorheology Research Institute, Jeonbuk National University, Jeon-ju 54896, Korea

Authors to whom correspondence should be addressed.

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These authors have contributed equally to this paper.

Academic Editor: Giovanni Scambia

J. Pers. Med. 2021, 11(4), 253; https://doi.org/10.3390/jpm11040253

Received: 3 March 2021 / Revised: 23 March 2021 / Accepted: 27 March 2021 / Published: 30 March 2021

(This article belongs to the Special Issue Personalized Medicine and Multidisciplinary Approach in a Clinical Research Hospital)

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Abstract

A multimodality approach was applied using four-dimensional flow magnetic resonance imaging (4D flow MRI), time-of-flight magnetic resonance angiography (TOF-MRA) signal intensity gradient (SIG), and computational fluid dynamics (CFD) to investigate the 3D blood flow characteristics and wall shear stress (WSS) of the cerebral arteries. TOF-MRA and 4D flow MRI were performed on the major cerebral arteries in 16 healthy volunteers (mean age 34.7 ± 7.6 years). The flow rate measured with 4D flow MRI in the internal carotid artery, middle cerebral artery, and anterior cerebral artery were 3.8, 2.5, and 1.2 mL/s, respectively. The 3D blood flow pattern obtained through CFD and 4D flow MRI on the cerebral arteries showed reasonable consensus. CFD delivered much greater resolution than 4D flow MRI. TOF-MRA SIG and CFD WSS of the major cerebral arteries showed reasonable consensus with the locations where the WSS was relatively high. However, the visualizations were very different between TOF-MRA SIG and CFD WSS at the internal carotid artery bifurcations, the anterior cerebral arteries, and the anterior communicating arteries. 4D flow MRI, TOF-MRA SIG, and CFD are complementary methods that can provide additional insight into the hemodynamics of the human cerebral artery. View Full-Text

Keywords: hemodynamics visualization; cerebral arteries; four-dimensional flow magnetic resonance imaging (4D flow MRI); signal intensity gradient from time-of-flight magnetic resonance angiography (TOF-MRA SIG); computational fluid dynamics (CFD)

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MDPI and ACS Style

Ngo, M.T.; Lee, U.Y.; Ha, H.; Jin, N.; Chung, G.H.; Kwak, Y.G.; Jung, J.; Kwak, H.S. Comparison of Hemodynamic Visualization in Cerebral Arteries: Can Magnetic Resonance Imaging Replace Computational Fluid Dynamics? J. Pers. Med. 2021, 11, 253. https://doi.org/10.3390/jpm11040253

AMA Style

Ngo MT, Lee UY, Ha H, Jin N, Chung GH, Kwak YG, Jung J, Kwak HS. Comparison of Hemodynamic Visualization in Cerebral Arteries: Can Magnetic Resonance Imaging Replace Computational Fluid Dynamics? Journal of Personalized Medicine. 2021; 11(4):253. https://doi.org/10.3390/jpm11040253

Chicago/Turabian Style

Ngo, Minh T., Ui Y. Lee, Hojin Ha, Ning Jin, Gyung H. Chung, Yeong G. Kwak, Jinmu Jung, and Hyo S. Kwak. 2021. "Comparison of Hemodynamic Visualization in Cerebral Arteries: Can Magnetic Resonance Imaging Replace Computational Fluid Dynamics?" Journal of Personalized Medicine 11, no. 4: 253. https://doi.org/10.3390/jpm11040253

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Comparison of Hemodynamic Visualization in Cerebral Arteries: Can Magnetic Resonance Imaging Replace Computational Fluid Dynamics?

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