Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Sample Collection
2.2. Determination of Uremic Metabolites in Blood
2.3. Illumina-Based Microbial Profiling
2.4. Statistical Analysis
3. Results
3.1. Gut Microbiome Profiles in Different Stages of CKD
3.2. Correlates of Intestinal Microbiota Composition in CKD
3.3. Variation in Gut Microbiota Profiles in Different Stages of CKD
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Correlation to BSS | All CKD Stages (n = 111) | CKD Stage 1–2 (n = 37) | CKD Stage 3 (n = 44) | CKD Stage 4–5 (n = 33) | ||||
---|---|---|---|---|---|---|---|---|
Uremic Toxin | rs | p-Value | rs | p-Value | rs | p-Value | rs | p-Value |
Indoxyl sulfate | −0.173 | ns | −0.130 | ns | −0.054 | ns | −0.223 | ns |
Indole-3-acetic acid | −0.150 | ns | −0.035 | ns | −0.041 | ns | −0.206 | ns |
Hippuric acid | −0.343 | <0.001 | −0.366 | 0.036 | −0.153 | ns | −0.318 | ns |
p-Cresyl sulfate | −0.287 | 0.003 | −0.335 | ns | −0.134 | ns | −0.443 | 0.012 |
p-Cresyl glucuronide | −0.175 | ns | −0.105 | ns | −0.116 | ns | −0.340 | ns |
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Gryp, T.; Faust, K.; Van Biesen, W.; Huys, G.R.B.; Verbeke, F.; Speeckaert, M.; Raes, J.; Vaneechoutte, M.; Joossens, M.; Glorieux, G. Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease. J. Pers. Med. 2021, 11, 1118. https://doi.org/10.3390/jpm11111118
Gryp T, Faust K, Van Biesen W, Huys GRB, Verbeke F, Speeckaert M, Raes J, Vaneechoutte M, Joossens M, Glorieux G. Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease. Journal of Personalized Medicine. 2021; 11(11):1118. https://doi.org/10.3390/jpm11111118
Chicago/Turabian StyleGryp, Tessa, Karoline Faust, Wim Van Biesen, Geert R. B. Huys, Francis Verbeke, Marijn Speeckaert, Jeroen Raes, Mario Vaneechoutte, Marie Joossens, and Griet Glorieux. 2021. "Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease" Journal of Personalized Medicine 11, no. 11: 1118. https://doi.org/10.3390/jpm11111118