Next Article in Journal
Fatal Immunohaemolysis after the Consumption of the Poison Pax Mushroom: A Focus on the Diagnosis of the Paxillus Syndrome with the Aid of Two Case Reports
Previous Article in Journal
Psychological Response to a False Positive Ovarian Cancer Screening Test Result: Distinct Distress Trajectories and Their Associated Characteristics
Open AccessArticle

Value of Diffusion Weighted MRI with Quantitative ADC Map in Diagnosis of Malignant Thyroid Disease

1
Radiology Division, Hanoi Medical University, Hanoi 100000, Vietnam
2
Radiology Department, Hanoi Medical University Hospital, Hanoi 100000, Vietnam
3
Oncology Division, Hanoi Medical University, Hanoi 100000, Vietnam
4
AI Lab, Faculty of Information Technology, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
5
Institute for Research and Development, Duy Tan University, Danang 550000, Vietnam
6
Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam
7
School of Odonto Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam
*
Authors to whom correspondence should be addressed.
Diagnostics 2019, 9(4), 129; https://doi.org/10.3390/diagnostics9040129
Received: 11 August 2019 / Revised: 8 September 2019 / Accepted: 23 September 2019 / Published: 25 September 2019
(This article belongs to the Section Medical Imaging)
Thyroid nodule is a common disease in clinical practice. The diagnosis of malignant thyroid tumors determines the treatment strategy. Among a number of methods have claimed to help evaluating thyroid nodules, ultrasound is a usable one in spite of several disadvantages (dependent on the physician/technician, incomparable, etc.) and magnetic resonance imaging (MRI) accompanied by quantitative apparent diffusion coefficient (ADC) is a promising diagnostic tool. This study was designed to investigate the usefulness of ADC cut-off values and the protocol of thyroid MRI derived from quantitative diffusion weighted imaging (DWI) in differentiating benign and malignant thyroid nodules. The study was conducted on 93 patients with 128 thyroid nodules, diagnosed and underwent surgery at Hanoi Medical University Hospital. All the patients took thyroid MRI with different b levels (from 200 to 800). ADC value was calculated to each b level, and the statistical tests were conducted with the Statistical Package for Social Sciences (SPSS—Windows and Mac version 20) and STATA 12. The mean ADC with all the b ranging from 200 to 800 of malignant groups was significantly higher than the group of benign lesions (p from <0.001 to 0.01). We chose b = 500 as a standard b-value in the protocol of thyroid MRI. The ADC cut-off point for distinguishing malignant from benign thyroid lesions: 1.7 × 10−3 mm2/s with high accuracy (87.1%, 95% CI: 79.59–92.07%). The study revealed that quantitative diffusion weighted MRI with ADC measurement could potentially quantitatively differentiate between benign and malignant thyroid nodules. View Full-Text
Keywords: quantitative ADC map; diagnosis; malignant thyroid disease; Vietnam quantitative ADC map; diagnosis; malignant thyroid disease; Vietnam
Show Figures

Figure 1

MDPI and ACS Style

Linh, L.T.; Cuong, N.N.; Hung, T.V.; Hieu, N.V.; Lenh, B.V.; Hue, N.D.; Pham, V.H.; Nga, V.T.; Chu, D.-T. Value of Diffusion Weighted MRI with Quantitative ADC Map in Diagnosis of Malignant Thyroid Disease. Diagnostics 2019, 9, 129.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop