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Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors—A Systematic Review and Meta-Analysis

by Hans-Jonas Meyer 1,*,†, Andreas Wienke 2,† and Alexey Surov 1,†
Department of Diagnostic and Interventional Radiology, University of Leipzig, 04103 Leipzig, Germany
Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, 06112 Halle (Saale), Germany
Author to whom correspondence should be addressed.
The authors contributed equally to this work.
Diagnostics 2019, 9(4), 126;
Received: 30 August 2019 / Revised: 18 September 2019 / Accepted: 20 September 2019 / Published: 23 September 2019
(This article belongs to the Special Issue Role of Radiological Imaging in Cancer Histopathology and Staging)
To date, only a few studies have investigated relationships between Diffusion-weighted imaging (DWI) and Vascular endothelial growth factor (VEGF) expression in tumors. The reported results are contradictory. The aim of the present analysis was to review the published results and to perform a meta-analysis regarding associations between apparent diffusion coefficients (ADC) derived from DWI and VEGF expression. MEDLINE library was screened for relationships between ADC and VEGF expression up to January 2019. Overall, 14 studies with 578 patients were identified. In 10 studies (71.4%) 3 T scanners were used and in four studies (28.6%) 1.5 T scanners. Furthermore, seven studies (50%) had a prospective design and seven studies (50%) had a retrospective design. Most frequently, prostate cancer, followed by rectal cancer, cervical cancer and esophageal cancer were identified. The pooled correlation coefficient of all tumors was r = −0.02 [95% CI −0.26–0.21]. ADC values derived from routinely acquired DWI do not correlate with VEGF expression in various tumors. Therefore, DWI is not sensitive enough to reflect angiogenesis-related microstructure of tumors. View Full-Text
Keywords: meta-analysis; DWI; ADC; VEGF meta-analysis; DWI; ADC; VEGF
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Meyer, H.-J.; Wienke, A.; Surov, A. Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors—A Systematic Review and Meta-Analysis. Diagnostics 2019, 9, 126.

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