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Diagnostics 2019, 9(1), 3; https://doi.org/10.3390/diagnostics9010003

18F-FDG PET/CT Findings in Cytomegalovirus Colitis

1
Department of Infectious diseases, Copenhagen University Hospital Hvidovre, Kettegaards Allé 30, DK-2650 Hvidovre, Denmark
2
Department of Clinical microbiology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark
3
Department of Patology, Copenhagen University Hospital Hvidovre, Kettegaards Allé 30, DK-2650 Hvidovre, Denmark
4
Department of Radiology, Copenhagen University Hospital Hvidovre, Kettegaards Allé 30, DK-2650 Hvidovre, Denmark
5
Department of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital Hvidovre, Kettegaards Allé 30, DK-2650 Hvidovre, Denmark
*
Author to whom correspondence should be addressed.
Received: 2 November 2018 / Revised: 13 December 2018 / Accepted: 21 December 2018 / Published: 26 December 2018
(This article belongs to the Collection Hybrid Imaging in Medicine)
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Abstract

We present a case demonstrating the diagnostic work-up of a patient undergoing azathioprine treatment for inflammatory bowel disease (IBD), diagnosed with an acute cytomegalovirus (CMV) infection and CMV colitis. An 18F-FDG positron emission tomography/computed tomography (PET/CT) performed 2 weeks after debut of symptoms revealed pathological 18F-FDG uptake in the left side of the colon mucosa, mimicked activity of IBD. However, a diagnosis of CMV colitis was based on the presence of CMV IgM antibodies, a seroconversion of CMV IgG antibodies, presence of CMV DNA in plasma and the finding af CMV DNA in biopsies from the intestinal mucosa. The patient responded to treatment with ganciclovir. This case highlights that a positive 18F-FDG PET/CT scan of the colon can be due to CMV colitis. View Full-Text
Keywords: 18F-FDG PET/CT; cytomegalovirus colitis; inflammatory bowel disease 18F-FDG PET/CT; cytomegalovirus colitis; inflammatory bowel disease
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Kjaer, A.S.L.; Ribberholt, I.; Thomsen, K.; Ibsen, P.H.; Markova, E.; Graff, J. 18F-FDG PET/CT Findings in Cytomegalovirus Colitis. Diagnostics 2019, 9, 3.

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