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Diagnostics 2018, 8(2), 30; https://doi.org/10.3390/diagnostics8020030

Circulating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis

1
London Regional Cancer Program, London Health Sciences Centre, Department of Anatomy & Cell Biology, Western University, London, ON N6A 5W9, Canada
2
Flow Cytometry and Special Hematology, London Health Sciences Centre, London, ON N6A 5W9, Canada
3
London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada
4
London Regional Cancer Program, London Health Sciences Centre, Departments of Anatomy & Cell Biology and Oncology, Lawson Health Research Institute, Western University, London, ON N6A 5W9, Canada
*
Author to whom correspondence should be addressed.
Received: 1 April 2018 / Revised: 24 April 2018 / Accepted: 24 April 2018 / Published: 28 April 2018
(This article belongs to the Special Issue Circulating Tumor Cells as Cancer Diagnostic Biomarkers)
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Abstract

The majority of cancer deaths occur because of metastasis since current therapies are largely non-curative in the metastatic setting. The use of in vivo preclinical mouse models for assessing metastasis is, therefore, critical for developing effective new cancer biomarkers and therapies. Although a number of quantitative tools have been previously developed to study in vivo metastasis, the detection and quantification of rare metastatic events has remained challenging. This review will discuss the use of circulating tumor cell (CTC) analysis as an effective means of tracking and characterizing metastatic disease progression in preclinical mouse models of breast and prostate cancer and the resulting lessons learned about CTC and metastasis biology. We will also discuss how the use of clinically-relevant CTC technologies such as the CellSearch® and Parsortix™ platforms for preclinical CTC studies can serve to enhance the study of cancer biology, new biomarkers, and novel therapies from the bench to the bedside. View Full-Text
Keywords: circulating tumor cells; preclinical models; metastasis circulating tumor cells; preclinical models; metastasis
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Kitz, J.; Lowes, L.E.; Goodale, D.; Allan, A.L. Circulating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis. Diagnostics 2018, 8, 30.

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