Next Article in Journal
The Clinical Relevance of Methods for Handling Inconclusive Medical Test Results: Quantification of Uncertainty in Medical Decision-Making and Screening
Next Article in Special Issue
The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy
Previous Article in Journal / Special Issue
Circulating Tumor Cell Analysis in Preclinical Mouse Models of Metastasis
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Diagnostics 2018, 8(2), 31; https://doi.org/10.3390/diagnostics8020031

Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations

1
Cancer Metastasis Laboratory, Department of Biomedicine, University of Basel and University Hospital Basel, 4058 Basel, Switzerland
2
Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
3
Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland
4
Hepatology Laboratory, Department of Biomedicine, University of Basel and University Hospital Basel, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Received: 15 April 2018 / Revised: 4 May 2018 / Accepted: 7 May 2018 / Published: 9 May 2018
(This article belongs to the Special Issue Circulating Tumor Cells as Cancer Diagnostic Biomarkers)
Full-Text   |   PDF [270 KB, uploaded 9 May 2018]

Abstract

The field of cancer diagnostics has recently been impacted by new and exciting developments in the area of liquid biopsy. A liquid biopsy is a minimally invasive alternative to surgical biopsies of solid tissues, typically achieved through the withdrawal of a blood sample or other body fluids, allowing the interrogation of tumor-derived material including circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) fragments that are present at a given time point. In this short review, we discuss a few studies that summarize the state-of-the-art in the liquid biopsy field from a diagnostic perspective, and speculate on current challenges and expectations of implementing liquid biopsy testing for cancer diagnosis and monitoring in the clinical setting. View Full-Text
Keywords: circulating tumor cells; single cell analysis; deep-sequencing; liquid biopsy; cancer diagnosis; cancer treatment circulating tumor cells; single cell analysis; deep-sequencing; liquid biopsy; cancer diagnosis; cancer treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Castro-Giner, F.; Gkountela, S.; Donato, C.; Alborelli, I.; Quagliata, L.; Ng, C.K.Y.; Piscuoglio, S.; Aceto, N. Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations. Diagnostics 2018, 8, 31.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diagnostics EISSN 2075-4418 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top