Relationship Between Right Ventricular Function and Body Composition in Adolescents and Young Adults
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Echocardiographic Assessment
2.3. Laboratory Parameters
2.4. Body Composition Scale
2.5. Statistical Analysis
3. Results
3.1. Echocardiographic Findings
3.2. Correlations with Body Composition
3.3. Trend Analysis
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
2D RV4CLS | Two-dimensional global longitudinal strain of the right ventricle |
2D RVFWLS | Two-dimensional longitudinal strain of the free wall of the right ventricle |
3D | Three-dimensional |
BMI | Body mass index |
CMR | Cardiac Magnetic Resonance |
CVD | Cardiovascular diseases |
ECW | Extracellular water |
EF | Ejection fraction |
FAC | Change in fractional area change |
HF | Heart failure |
ICW | Intracellular water |
LV | Left ventricle |
PASP | Systolic pressure in the pulmonary artery |
RV | Right ventricle |
RVBD, RVMD | Basal and mid-ventricular diameter of the RV |
S’ | Maximum velocity of lateral tricuspid annular motion during systole |
TAPSE | Amplitude of lateral tricuspid annular motion |
TBW | Total Body Water |
TR | Tricuspid regurgitation |
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Overweight or Obesity N = 55 | Normal Weight N = 25 | r | p | |
---|---|---|---|---|
Demographics | ||||
Female, n (%) | 23 (42) | 10 (40) | 0.081 | |
Age, years | 19.5 ± 2.8 | 20.4 ± 2.96 | 0.816 | |
Weight (kg) | 77.1 ± 3.9 | 71.8 ± 2.7 | 0.005 | |
Height (cm) | 173.2 ± 4.7 | 175.4 ± 4.5 | 0.005 | |
BMI (kg/m2) | 31.4 ± 4.0 | 21.5 ± 2.0 | p < 0.0001 | |
Caucasian ethnicity (%) | 55 (100) | 25 (100) | ||
Clinical characteristics | ||||
SBP, mmHg | 122 ± 21 | 121 ± 19 | 0.008 | |
DBP, mmHg | 75 ± 12 | 77 ± 13 | 0.007 | |
24 h SBP, mmHg | 109 ± 11 | 111 ± 13 | 0.005 | |
24 h DBP, mmHg | 66 ± 9 | 67 ± 9 | 0.076 | |
Heart rate, bpm | 64 ± 10 | 65 ± 11 | 0.214 | |
24 h heart rate, bpm | 65 ± 10 | 67 ± 11 | 0.459 | |
Smoker, n (%) | 9 (16) | 4 (16) | 0.573 | |
Laboratory parameters | ||||
AST, μkat/L | 0.47 ± 0.21 | 0.41 ± 0.13 | −0.18 | 0.249 |
ALT, μkat/L | 0.46 ± 0.31 | 0.31 ± 0.16 | −0.16 | 0.061 |
GGT, μkat/L | 0.39 ± 0.24 | 0.26 ± 0.07 | −0.05 | 0.819 |
CHOL, mmol/L | 4.33 ± 0.64 | 4.24 ± 0.74 | −0.19 | 0.312 |
TAG, mmol/L | 1.15 ± 0.54 | 0.79 ± 0.40 | −0.09 | 0.624 |
LDL, mmol/L | 2.84 ± 0.72 | 2.54 ± 0.62 | −0.22 | 0.238 |
HDL, mmol/L | 1.26 ± 0.42 | 1.57 ± 0.41 | −0.04 | 0.796 |
Albumin, g/L | 45.62 ± 2.23 | 45.65 ± 2.55 | 0.09 | 0.085 |
Uric acid, mmol/L | 325.89 ± 80.26 | 269.83 ± 82.70 | 0.08 | 0.552 |
Total serum protein, kg | 72.46 ± 2.97 | 73.85 ± 3.73 | 0.10 | 0.074 |
C-peptide, nmol/L | 1242.61 ± 619.82 | 712.1 ± 385.2 | 0.13 | 0.306 |
Insulin, mmol/L | 13.37 ± 6.57 | 10.01 ± 6.90 | 0.05 | 0.495 |
Body composition | ||||
Total water, L | 45.53 ± 8.64 | 38.21 ± 7.45 | 0.24 | 0.083 |
Total minerals, kg | 4.03 ± 0.83 | 3.47 ± 0.60 | 0.29 | 0.057 |
Fat mass, kg | 25.46 ± 13.39 | 9.83 ± 5.36 | −0.41 | 0.035 |
Lean body mass, kg | 62.84 ± 11.53 | 52.03 ± 10.11 | 0.59 | 0.009 |
Echocardiography | ||||
RVBD (mm) | 35.4 ± 3.6 | 31.9 ± 3.9 | 0.67 | p < 0.05 |
RVMD (mm) | 27.8 ± 3.9 | 25.7 ± 3.9 | 0.12 | p < 0.04 |
FAC (%) | 44.7 ± 5.0 | 46.4 ± 5.6 | 0.15 | ns |
2D RVFWLS (%) | 20.8 ± 5.2 | 27.6 ± 4.0 | 0.32 | p < 0.001 |
2D RV4CLS (%) | 18.2 ± 3.8 | 23.3 ± 3.6 | 0.29 | p < 0.001 |
LVEF, % | 56.70 ± 3.90 | 58.40 ± 4.25 | −0.24 | p <0.01 |
S’(cm/s) | 13.1 ± 1.6 | 14.1 ± 1.64 | −0.09 | p < 0.01 |
TAPSE, mm | 22.93 ± 2.5 | 23.1 ± 2.5 | −0.16 | ns |
PASP, mmHg | 26.57 ± 5.7 | 22.7 ± 4.7 | 0.21 | p < 0.01 |
Echocardiographic Parameters | Body Composition Parameters | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
TP | TW | MIN | FM | LBM | ||||||
r | p | r | p | r | p | r | p | r | p | |
S’ (cm/s) | −0.10 | <0.01 | −0.09 | ns | −0.06 | ns | −0.02 | <0.01 | −0.11 | <0.01 |
TAPSE, mm | −0.17 | ns | −0.15 | ns | −0.01 | ns | −0.02 | ns | −0.11 | ns |
PASP, mmHg | 0.19 | <0.01 | 0.12 | ns | 0.09 | ns | 0.17 | <0.01 | 0.23 | <0.01 |
RVBD (mm) | 0.05 | <0.01 | −0.04 | ns | 0.12 | ns | 0.10 | <0.001 | 0.05 | <0.01 |
RVMD (mm) | 0.12 | <0.05 | 0.09 | ns | 0.13 | ns | 0.32 | <0.04 | 0.14 | <0.04 |
FAC (%) | 0.24 | ns | 0.23 | ns | 0.15 | ns | 0.30 | ns | 0.25 | ns |
2D RVFWLS (%) | −0.25 | <0.01 | 0.28 | ns | 0.32 | ns | −0.22 | <0.001 | 0.29 | <0.01 |
2D RV4CLS (%) | −0.24 | <0.01 | 0.26 | ns | 0.29 | ns | −0.29 | <0.001 | 0.29 | <0.001 |
Echocardiographic Parameters | Body Composition Parameters | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
TP | TW | MIN | FM | LBM | ||||||
r | p | r | p | r | p | r | p | r | p | |
S’ (cm/s) | −0.12 | <0.01 | −0.08 | ns | −0.05 | ns | −0.03 | <0.01 | −0.09 | <0.01 |
TAPSE, mm | −0.14 | ns | −0.13 | ns | −0.02 | ns | −0.01 | ns | −0.12 | ns |
PASP, mmHg | 0.21 | <0.01 | 0.11 | ns | 0.07 | ns | 0.18 | <0.01 | 0.22 | <0.01 |
RVBD (mm) | 0.06 | <0.01 | −0.03 | ns | 0.10 | ns | 0.11 | <0.05 | 0.06 | <0.01 |
RVMD (mm) | 0.14 | <0.05 | 0.10 | ns | 0.09 | ns | 0.33 | <0.05 | 0.15 | <0.04 |
FAC (%) | 0.21 | ns | 0.20 | ns | 0.18 | ns | 0.28 | ns | 0.23 | ns |
2D RVFWLS (%) | −0.28 | <0.01 | 0.27 | ns | 0.30 | ns | −0.17 | <0.001 | 0.29 | <0.01 |
2D RV4CLS (%) | −0.22 | <0.05 | 0.21 | ns | 0.28 | ns | −0.27 | <0.001 | 0.31 | <0.001 |
Echocardiographic Parameters | Body Composition Parameters | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
TP | TW | MIN | FM | LBM | ||||||
r | p | r | p | r | p | r | p | r | p | |
S’ (cm/s) | −0.11 | <0.01 | −0.07 | ns | −0.08 | ns | −0.04 | <0.01 | −0.10 | <0.001 |
TAPSE, mm | −0.16 | ns | −0.12 | ns | −0.03 | ns | −0.01 | ns | −0.09 | ns |
PASP, mmHg | 0.18 | <0.05 | 0.13 | ns | 0.10 | ns | 0.16 | <0.01 | 0.21 | <0.01 |
RVBD (mm) | 0.07 | <0.01 | −0.02 | ns | 0.09 | ns | 0.12 | <0.001 | 0.07 | <0.01 |
RVMD (mm) | 0.14 | <0.05 | 0.08 | ns | 0.12 | ns | 0.30 | <0.04 | 0.13 | <0.04 |
FAC (%) | 0.23 | ns | 0.22 | ns | 0.14 | ns | 0.27 | ns | 0.26 | ns |
2D RVFWLS (%) | −0.27 | <0.01 | 0.29 | ns | 0.30 | ns | −0.23 | <0.01 | 0.28 | <0.01 |
2D RV4CLS (%) | −0.20 | <0.001 | 0.23 | ns | 0.25 | ns | −0.30 | <0.001 | 0.28 | <0.001 |
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Sieradzka Uchnar, K.A.; Toth, S.; Schusterova, I.; Pella, D.; Gurbalova, S.; Poruban, T. Relationship Between Right Ventricular Function and Body Composition in Adolescents and Young Adults. Diagnostics 2025, 15, 2487. https://doi.org/10.3390/diagnostics15192487
Sieradzka Uchnar KA, Toth S, Schusterova I, Pella D, Gurbalova S, Poruban T. Relationship Between Right Ventricular Function and Body Composition in Adolescents and Young Adults. Diagnostics. 2025; 15(19):2487. https://doi.org/10.3390/diagnostics15192487
Chicago/Turabian StyleSieradzka Uchnar, Karolina Angela, Stefan Toth, Ingrid Schusterova, Dominik Pella, Silvia Gurbalova, and Tibor Poruban. 2025. "Relationship Between Right Ventricular Function and Body Composition in Adolescents and Young Adults" Diagnostics 15, no. 19: 2487. https://doi.org/10.3390/diagnostics15192487
APA StyleSieradzka Uchnar, K. A., Toth, S., Schusterova, I., Pella, D., Gurbalova, S., & Poruban, T. (2025). Relationship Between Right Ventricular Function and Body Composition in Adolescents and Young Adults. Diagnostics, 15(19), 2487. https://doi.org/10.3390/diagnostics15192487