“Not All That Glitters Is Gold”: Paraspinal Cavernous Hemangioma Mimicking Paraganglioma on Somatostatin Receptor PET/CT

Figure 1. A 77-year-old male underwent computed tomography (CT) for evaluation of peripheral artery disease, which revealed a left paraspinal mass at the T11 level, adjacent to the costovertebral junction. The subsequent magnetic resonance imaging (MRI) revealed a 35 × 39 mm spinal/paraspinal lesion at the left Th11 level with homogeneous contrast enhancement, bone erosion, and sclerosis, suggestive of slow growth. Conventional imaging findings prompted consideration of both paraganglioma and a primary spinal tumor, particularly of chondroid origin, in the differential diagnosis. To assess for neuro-endocrine origin, the patient underwent plasma-free metanephrine screening and a somatostatin receptor positron emission tomography/contrast-enhanced-CT (SSTR-PET/CE-CT) scan with Gallium-68 DOTATATE (a radiolabeled somatostatin analog) for staging, given the well-established overexpression of somatostatin receptor subtype 2 (SSTR2) in neuroendocrine tumors [1,2,3]. Maximum intensity projection (MIP) PET image (A1), axial fused PET/CT (B1), PET (B2), and venous-phase CT image (B3) at the level of the orange line in A1 show the marked tracer accumulation corresponding to an expansile, osteoerosive, and hypervascular mass involving the left lateral margin of the Th11 vertebral body and pedicle (red arrows). Plasma-free metanephrine and catecholamine levels confirmed that the lesion was biochemically inactive, after which a CT-guided biopsy was considered safe and performed. Histopathology revealed a partially sclerotic, vascular lesion without atypia, consistent with cavernous hemangioma. Immunohistochemistry showed endothelial positivity for ERG, CD34, CD31, and SSTR2, and negativity for D2-40, chromogranin, synaptophysin, and INSM1, with Ki-67 < 5%. Strong endothelial SSTR2 expression accounted for the avid tracer uptake and the false-positive appearance mimicking paraganglioma on SSTR PET/CT. Although incidental hemangiomas localized in different anatomical sites have already been reported on SSTR-PET/CT with Gallium-68 DOTA-peptides [4,5,6,7,8,9,10,11], to our knowledge this is the first case documenting increased Gallium-68 DOTATATE uptake in a histologically confirmed cavernous hemangioma, a rare hemangioma subtype. According to a systematic review, incidental findings at SSTR-PET/CT mimicking neuroendocrine tumors are predominantly seen in the thyroid gland, spine, brain, and breast, and most of them are benign lesions [6]. Our case underscores the importance of considering cavernous hemangiomas in the differential diagnosis of SSTR-avid lesions, given their potential to mimic paragangliomas and other neuroendocrine tumors in both morphology and functional imaging characteristics.