Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography

Plekhanov, Anton A.; Grechkanev, Gennady O.; Avetisyan, Elena A.; Loginova, Maria M.; Kiseleva, Elena B.; Shepeleva, Anastasia A.; Moiseev, Alexander A.; Sovetsky, Alexander A.; Gubarkova, Ekaterina V.; Anina, Anastasia A.; Shutova, Angelina M.; Gamayunov, Sergey V.; Gelikonov, Grigory V.; Zaitsev, Vladimir Y.; Sirotkina, Marina A.; Gladkova, Natalia D.

doi:10.3390/diagnostics14192131

Open AccessArticle

Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography

by

Anton A. Plekhanov

^1,*

,

Gennady O. Grechkanev

¹

,

Elena A. Avetisyan

²,

Maria M. Loginova

¹,

Elena B. Kiseleva

¹

,

Anastasia A. Shepeleva

²,

Alexander A. Moiseev

³,

Alexander A. Sovetsky

³,

Ekaterina V. Gubarkova

¹

,

Anastasia A. Anina

^1,4,

Angelina M. Shutova

¹,

Sergey V. Gamayunov

²

,

Grigory V. Gelikonov

³,

Vladimir Y. Zaitsev

³

,

Marina A. Sirotkina

¹ and

Natalia D. Gladkova

¹

Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Sq., 603950 Nizhny Novgorod, Russia

²

Nizhny Novgorod Regional Oncological Hospital, 11/1 Delovaya St., 603093 Nizhny Novgorod, Russia

³

A.V. Gaponov-Grekhov Institute of Applied Physics The Russian Academy of Sciences, 46 Ulyanova St., 603950 Nizhny Novgorod, Russia

⁴

Lobachevsky University, 23 Gagarin Av., 603022 Nizhny Novgorod, Russia

^*

Author to whom correspondence should be addressed.

Diagnostics 2024, 14(19), 2131; https://doi.org/10.3390/diagnostics14192131

Submission received: 28 August 2024 / Revised: 20 September 2024 / Accepted: 23 September 2024 / Published: 25 September 2024

(This article belongs to the Special Issue Imaging for the Diagnosis of Obstetric and Gynecological Diseases)

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Abstract

Objectives: The most important phase in the endometrial pathologies diagnostics is the histological examination of tissue biopsies obtained under visual hysteroscopic control. However, the unclear visual diagnostics characteristics of subtle focal endometrial pathologies often lead to selection errors regarding suspicious endometrial lesions and to a subsequent false pathological diagnosis/underestimation of precancer or early-stage cancer. Methods: In this study, we investigate the potential of Multimodal Optical Coherence Tomography (MM OCT) to verify suspicious endometrial lesion regions before biopsy collection. We study the polarization (by cross-polarization OCT, CP OCT) and elastic (by compression OCT-elastography, C-OCE) properties of ex vivo endometrial tissue samples in normal conditions (proliferative and secretory phases to the menstrual cycle, atrophic endometrium) with endometrial hyperplasia (non-atypical and endometrial intraepithelial neoplasia) and endometrial cancer subtypes (low-grade, high-grade, clear cell and serous). Results: To the best of our knowledge, this is the first quantitative assessment of relevant OCT parameters (depth-resolved attenuation coefficient in co-[Att(co) values] and cross-[(Att(cross) values] polarizations and Young’s elastic modulus [stiffness values]) for the selection of the most objective criteria to identify the clinically significant endometrial pathologies: endometrial intraepithelial neoplasia and endometrial cancer. The study demonstrates the possibility of detecting endometrial pathologies and establishing optimal threshold values of MM OCT criteria for the identification of endometrial cancer using CP OCT (by Att(co) values = 3.69 mm⁻¹, Sensitivity (Se) = 86.1%, Specificity (Sp) = 92.6%; by Att(cross) values = 2.27 mm⁻¹, Se = 86.8%, Sp = 87.0%) and C-OCE (by stiffness values = 122 kPa, Se = 93.2%, Sp = 91.1%). The study also differentiates endometrial intraepithelial neoplasia from non-atypical endometrial hyperplasia and normal endometrium using C-OCE (by stiffness values = 95 kPa, Se = 87.2%, Sp = 90.1%). Conclusions: The results are indicative of the efficacy and potential of clinical implementation of in vivo hysteroscopic-like MM OCT in the diagnosis of endometrial pathologies.

Keywords: endometrial hyperplasia; cancer; optical coherence tomography; cross-polarization OCT; elastography; attenuation coefficient

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MDPI and ACS Style

Plekhanov, A.A.; Grechkanev, G.O.; Avetisyan, E.A.; Loginova, M.M.; Kiseleva, E.B.; Shepeleva, A.A.; Moiseev, A.A.; Sovetsky, A.A.; Gubarkova, E.V.; Anina, A.A.; et al. Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography. Diagnostics 2024, 14, 2131. https://doi.org/10.3390/diagnostics14192131

AMA Style

Plekhanov AA, Grechkanev GO, Avetisyan EA, Loginova MM, Kiseleva EB, Shepeleva AA, Moiseev AA, Sovetsky AA, Gubarkova EV, Anina AA, et al. Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography. Diagnostics. 2024; 14(19):2131. https://doi.org/10.3390/diagnostics14192131

Chicago/Turabian Style

Plekhanov, Anton A., Gennady O. Grechkanev, Elena A. Avetisyan, Maria M. Loginova, Elena B. Kiseleva, Anastasia A. Shepeleva, Alexander A. Moiseev, Alexander A. Sovetsky, Ekaterina V. Gubarkova, Anastasia A. Anina, and et al. 2024. "Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography" Diagnostics 14, no. 19: 2131. https://doi.org/10.3390/diagnostics14192131

APA Style

Plekhanov, A. A., Grechkanev, G. O., Avetisyan, E. A., Loginova, M. M., Kiseleva, E. B., Shepeleva, A. A., Moiseev, A. A., Sovetsky, A. A., Gubarkova, E. V., Anina, A. A., Shutova, A. M., Gamayunov, S. V., Gelikonov, G. V., Zaitsev, V. Y., Sirotkina, M. A., & Gladkova, N. D. (2024). Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography. Diagnostics, 14(19), 2131. https://doi.org/10.3390/diagnostics14192131

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Quantitative Assessment of Polarization and Elastic Properties of Endometrial Tissue for Precancer/Cancer Diagnostics Using Multimodal Optical Coherence Tomography

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