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Volume 14
Issue 17
10.3390/diagnostics14171907
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Review

Monoclonal Gammopathy of Clinical Significance (MGCS) and Related Disorders: A Review and the Role of Imaging

by
Ahmed O. El Sadaney
1,
Anika Dutta
1,
Joselle Cook
2 and
Francis I. Baffour
1,*
1
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
2
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Diagnostics 2024, 14(17), 1907; https://doi.org/10.3390/diagnostics14171907
Submission received: 17 July 2024 / Revised: 21 August 2024 / Accepted: 27 August 2024 / Published: 29 August 2024
(This article belongs to the Special Issue Advances in Multiple Myeloma Imaging)
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Abstract

The term monoclonal gammopathy of clinical significance (MGCS) refers to a group of symptomatic monoclonal gammopathies that do not meet the diagnostic criteria for malignant plasma cell disorders, such as multiple myeloma or Waldenström macroglobulinemia. These symptoms are attributable to the paraneoplastic effects of monoclonal immunoglobulins that occur through diverse mechanisms. The presence of symptoms distinguishes MGCS from monoclonal gammopathy of undetermined significance, which lacks significant symptomatic presentation. The presentations of MGCS are manifold, adding to the diagnostic challenge. Clinical suspicion is key for accurate and timely diagnosis. Radiologic imaging can provide pivotal information to guide the diagnosis. In this review, we discuss MGCS from a radiology perspective and highlight pertinent imaging features associated with the disorders.
Keywords: MGCS; MGUS; multiple myeloma; POEMS; amyloidosis MGCS; MGUS; multiple myeloma; POEMS; amyloidosis

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MDPI and ACS Style

El Sadaney, A.O.; Dutta, A.; Cook, J.; Baffour, F.I. Monoclonal Gammopathy of Clinical Significance (MGCS) and Related Disorders: A Review and the Role of Imaging. Diagnostics 2024, 14, 1907. https://doi.org/10.3390/diagnostics14171907

AMA Style

El Sadaney AO, Dutta A, Cook J, Baffour FI. Monoclonal Gammopathy of Clinical Significance (MGCS) and Related Disorders: A Review and the Role of Imaging. Diagnostics. 2024; 14(17):1907. https://doi.org/10.3390/diagnostics14171907

Chicago/Turabian Style

El Sadaney, Ahmed O., Anika Dutta, Joselle Cook, and Francis I. Baffour. 2024. "Monoclonal Gammopathy of Clinical Significance (MGCS) and Related Disorders: A Review and the Role of Imaging" Diagnostics 14, no. 17: 1907. https://doi.org/10.3390/diagnostics14171907

APA Style

El Sadaney, A. O., Dutta, A., Cook, J., & Baffour, F. I. (2024). Monoclonal Gammopathy of Clinical Significance (MGCS) and Related Disorders: A Review and the Role of Imaging. Diagnostics, 14(17), 1907. https://doi.org/10.3390/diagnostics14171907

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