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Diagnostics
Volume 13
Issue 7
10.3390/diagnostics13071311
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Review
Peer-Review Record

Pathomorphological Diagnostic Criteria for Focal Cortical Dysplasias and Other Common Epileptogenic Lesions—Review of the Literature

Diagnostics 2023, 13(7), 1311; https://doi.org/10.3390/diagnostics13071311
by Dimitar Metodiev 1,2,*, Krassimir Minkin 3, Margarita Ruseva 4,*, Rumiana Ganeva 4, Dimitar Parvanov 4 and Sevdalin Nachev 1
Reviewer 1:
Omar El Hiba
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Diagnostics 2023, 13(7), 1311; https://doi.org/10.3390/diagnostics13071311
Submission received: 14 February 2023 / Revised: 20 March 2023 / Accepted: 28 March 2023 / Published: 31 March 2023
(This article belongs to the Special Issue Advances in the Diagnosis of Nervous System Diseases)

Round 1

Reviewer 1 Report

This literature review on the diagnostic of focal cortical dysplasia gives clear description of the pathological features and classifications. In my point of view, it is of a significant contribution. 

I have only one remark regarding the reference 127, not figuring on the text.

Author Response

We would like to thank Reviewer 1 for taking the necessary time and effort to review the manuscript!

There was a technicall error with the numbering of the reference list which has now been corrected.

Reviewer 2 Report

Comments and suggestion Suggestions for the author:

Define pharmacoresistant epilepsy in simple terms so that readers who may not be familiar with the term can understand the abstract better.

Summarize some of the key findings from the literature on the morphological changes observed in patients with pharmacoresistant epilepsy in a concise manner.

Explain why the new histologically defined pathological entities discussed in the 2022 revision of the ILAE FCD classification are significant and how they differ from previous classifications.

Provide examples of novel treatment strategies based on genetic variants in FCD and explain how they might be implemented in clinical practice.

Include a brief summary of the key findings discussed in the paper in the conclusion to reinforce the main points for the reader.

Suggest specific research directions that could help advance our understanding of FCD in conclusion, such as the potential for genetic studies or imaging studies to shed light on the underlying mechanisms of FCD.

Summarize some of the pathomorphological characteristics of individual forms of FCD briefly in the conclusion to reinforce the main points of the paper.

Provide examples of other epileptogenic lesions associated with FCD and explain how they contribute to the development of pharmacoresistant epilepsy in patients with FCD.

Please cross check the references with manuscript to cite the exact reference.

 

Thank you. 

 

Author Response

Please see the attachment which includes a point-by-point response to each of the reviewer’s comments.

Author Response File: Author Response.docx

Reviewer 3 Report

Nice job. In this review, the authors summarized the pathomorphological characteristics of the FCD and other common epileptogenic lesions. The rich illustrations undoubtedly help the reader to understand these pathomorphological diagnostic criteria.

Author Response

We would like to thank Reviewer 3 for taking the time and effort to review our manuscript. We really appreciate the reviewer's positive comments.

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