Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study
Abstract
:1. Introduction
2. Patients and Methods
2.1. Patients
2.2. CT Protocol
2.3. Image Analysis
2.3.1. Observation and Measurement of Nodules
2.3.2. Category of Pulmonary Nodules
2.4. Statisticalanalysis
3. Results
3.1. General Data Statistics of Patients
3.1.1. Consistency between Observers
3.1.2. Comparison of Diagnostic Accuracy between Original and Modified Versions for pGGN
3.1.3. Difference of Diagnostic Performance of SNs between Original and Modified Versions
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Category | Solid Nodule (SN) | Pure Ground Glass Nodule (pGGN) | ||
---|---|---|---|---|
OV | MV | OV | MV | |
2 | <6 mm at baseline OR new < 4 mm Juxtapleural nodule: <10 mm mean diameter at baseline or new AND Solid; smooth margins; oval, lentiform, or triangular shape | <6 mm at baseline OR new < 4 mm; Category 3 or 4 nodules without spiculation and with additional features (≥1 sign) that indicate the suspicion of benign disease; Category 3 nodules unchanged for ≥6 months Juxtapleural nodule: <10 mm mean diameter at baseline or new AND solid; smooth margins; oval, lentiform, or triangular shape | <30 mm at baseline, new, or growing OR ≥30 mm stable or slow-growing | <30 mm and type I GVR; Category 3 or 4 nodules stable ≥ 5 years; Category 3 or 4 nodules decreased in size and there was an absence of solid components OR this was resolved on a follow-up |
3 | ≥6 to <8 mm at baseline; new 4 mm to <6 mm; Category 4A nodule that is stable or decreased in size at 3-month follow-up CT (excluding airway nodules) | ≥6 to <8 mm at baseline; new 4 mm to <6 mm Category 4A nodules unchanged for ≥3 months | ≥30 mm at baseline or new | ≥30 mm and type I GVR; any size with type II GVR |
4A | ≥8 to <15 mm at baseline OR Growing < 8 mm OR New 6 to <8 mm | ≥8 to <15 mm at baseline; growing < 8 mm; new 6 to <8 mm | - | any size with type III GVR |
4B | ≥15 mm at baseline OR New or growing ≥ 8 mm | ≥15 mm at baseline; new or growing, and ≥8 mm | - | any size with type IV GVR |
4X | Category 3 or 4 nodules with additional features or imaging findings that increase suspicion for lung cancer | Category 3 or 4 nodules with additional features or imaging findings that increase the suspicion of malignancy and lack benign signs; Category 3 or 4 nodules with spiculation sign with or without benign signs | Category 3 or 4 nodules with additional features or imaging findings that increase suspicion for lung cancer | Category 3 or 4 nodules with additional features or imaging findings that increases the suspicion of malignancy |
OV | MV | χ2 | p | |
---|---|---|---|---|
TP | 0 | 67 | - | - |
FP | 0 | 5 | - | - |
TN | 21 | 16 | - | - |
FN | 69 | 2 | - | - |
Sensitivity (%) | 0 | 97.10 | - | - |
Specificity (%) | 100 | 76.19 | - | - |
AR (%) | 23.33 | 92.22 | 87.54 | <0.001 # |
OV | MV | χ2 | p | |
---|---|---|---|---|
TP | 164 | 164 | - | - |
FP | 20 | 9 | - | - |
TN | 16 | 27 | - | - |
FN | 3 | 3 | - | - |
Sensitivity (%) | 98.20 | 98.20 | - | - |
Specificity (%) | 44.44 | 75.00 | - | 0.002 * |
AR (%) | 88.67 | 94.09 | 3.78 | 0.052 # |
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Song, F.; Fu, B.; Liu, M.; Liu, X.; Liu, S.; Lv, F. Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study. Diagnostics 2023, 13, 2210. https://doi.org/10.3390/diagnostics13132210
Song F, Fu B, Liu M, Liu X, Liu S, Lv F. Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study. Diagnostics. 2023; 13(13):2210. https://doi.org/10.3390/diagnostics13132210
Chicago/Turabian StyleSong, Feipeng, Binjie Fu, Mengxi Liu, Xiangling Liu, Sizhu Liu, and Fajin Lv. 2023. "Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study" Diagnostics 13, no. 13: 2210. https://doi.org/10.3390/diagnostics13132210
APA StyleSong, F., Fu, B., Liu, M., Liu, X., Liu, S., & Lv, F. (2023). Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study. Diagnostics, 13(13), 2210. https://doi.org/10.3390/diagnostics13132210