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Diagnostics
Volume 12
Issue 9
10.3390/diagnostics12092255
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Article

Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19

by
Min-Kyu Kang
1,†,
Yu-Rim Lee
2,†,
Jeung-Eun Song
3,
Young-Oh Kweon
2,
Won-Young Tak
2,
Se-Young Jang
2,
Jung-Gil Park
1,* and
Soo-Young Park
2,*
1
Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea
2
Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41994, Korea
3
Department of Internal Medicine, School of Medicine, Daegu Catholic University, Daegu 42472, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2022, 12(9), 2255; https://doi.org/10.3390/diagnostics12092255
Submission received: 13 August 2022 / Revised: 15 September 2022 / Accepted: 16 September 2022 / Published: 18 September 2022
(This article belongs to the Special Issue Advancements on Diagnostic and Management of Liver Disease)
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Abstract

Body composition, including sarcopenia, adipose tissue, and myosteatosis, is associated with unfavorable clinical outcomes in patients with coronavirus disease (COVID-19). However, few studies have identified the impact of body composition, including pre-existing risk factors, on COVID-19 mortality. Therefore, this study aimed to evaluate the effect of body composition, including pre-existing risk factors, on mortality in hospitalized patients with COVID-19. This two-center retrospective study included 127 hospitalized patients with COVID-19 who underwent unenhanced chest computed tomography (CT) between February and April 2020. Using the cross-sectional CT images at the L2 vertebra level, we analyzed the body composition, including skeletal muscle mass, visceral to subcutaneous adipose tissue ratio (VSR), and muscle density using the Hounsfield unit (HU). Of 127 patients with COVID-19, 16 (12.6%) died. Compared with survivors, non-survivors had low muscle density (41.9 vs. 32.2 HU, p < 0.001) and high proportion of myosteatosis (4.5 vs. 62.5%, p < 0.001). Cox regression analyses revealed diabetes (hazard ratio [HR], 3.587), myosteatosis (HR, 3.667), and a high fibrosis-4 index (HR, 1.213) as significant risk factors for mortality in patients with COVID-19. Myosteatosis was associated with mortality in hospitalized patients with COVID-19, independent of pre-existing prognostic factors.
Keywords: COVID-19; myosteatosis; visceral adiposity; sarcopenia; body composition COVID-19; myosteatosis; visceral adiposity; sarcopenia; body composition

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MDPI and ACS Style

Kang, M.-K.; Lee, Y.-R.; Song, J.-E.; Kweon, Y.-O.; Tak, W.-Y.; Jang, S.-Y.; Park, J.-G.; Park, S.-Y. Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19. Diagnostics 2022, 12, 2255. https://doi.org/10.3390/diagnostics12092255

AMA Style

Kang M-K, Lee Y-R, Song J-E, Kweon Y-O, Tak W-Y, Jang S-Y, Park J-G, Park S-Y. Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19. Diagnostics. 2022; 12(9):2255. https://doi.org/10.3390/diagnostics12092255

Chicago/Turabian Style

Kang, Min-Kyu, Yu-Rim Lee, Jeung-Eun Song, Young-Oh Kweon, Won-Young Tak, Se-Young Jang, Jung-Gil Park, and Soo-Young Park. 2022. "Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19" Diagnostics 12, no. 9: 2255. https://doi.org/10.3390/diagnostics12092255

APA Style

Kang, M.-K., Lee, Y.-R., Song, J.-E., Kweon, Y.-O., Tak, W.-Y., Jang, S.-Y., Park, J.-G., & Park, S.-Y. (2022). Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19. Diagnostics, 12(9), 2255. https://doi.org/10.3390/diagnostics12092255

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