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Diagnostics
Volume 12
Issue 8
10.3390/diagnostics12081775
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Communication

Features Found in Indocyanine Green-Based Fluorescence Optical Imaging of Inflammatory Diseases of the Hands

by
Egbert Gedat
1,2,*,
Jörn Berger
2,
Denise Kiesel
3,
Vieri Failli
2,
Andreas Briel
2 and
Pia Welker
3
1
Faculty of Engineering and Natural Sciences, Wildau Technical University of Applied Sciences, 15745 Wildau, Germany
2
Xiralite GmbH, 10115 Berlin, Germany
3
Institute of Functional Anatomy, Charité Universitätsmedizin Berlin, 10115 Berlin, Germany
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(8), 1775; https://doi.org/10.3390/diagnostics12081775
Submission received: 31 May 2022 / Revised: 13 July 2022 / Accepted: 16 July 2022 / Published: 22 July 2022
(This article belongs to the Special Issue Fluorescence Optical Imaging)
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Abstract

Rheumatologists in Europe and the USA increasingly rely on fluorescence optical imaging (FOI, Xiralite) for the diagnosis of inflammatory diseases. Those include rheumatoid arthritis, psoriatic arthritis, and osteoarthritis, among others. Indocyanine green (ICG)-based FOI allows visualization of impaired microcirculation caused by inflammation in both hands in one examination. Thousands of patients are now documented and most literature focuses on inflammatory arthritides, which affect synovial joints and their related structures, making it a powerful tool in the diagnostic process of early undifferentiated arthritis and rheumatoid arthritis. However, it has become gradually clear that this technique has the potential to go even further than that. FOI allows visualization of other types of tissues. This means that FOI can also support the diagnostic process of vasculopathies, myositis, collagenoses, and other connective tissue diseases. This work summarizes the most prominent imaging features found in FOI examinations of inflammatory diseases, outlines the underlying anatomical structures, and introduces a nomenclature for the features and, thus, supports the idea that this tool is a useful part of the imaging repertoire in rheumatology clinical practice, particularly where other imaging methods are not easily available.
Keywords: optical diagnosis imaging; fluorescence optical imaging; indocyanine green fluorescence; image feature; image analysis; rheumatoid diseases optical diagnosis imaging; fluorescence optical imaging; indocyanine green fluorescence; image feature; image analysis; rheumatoid diseases
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MDPI and ACS Style

Gedat, E.; Berger, J.; Kiesel, D.; Failli, V.; Briel, A.; Welker, P. Features Found in Indocyanine Green-Based Fluorescence Optical Imaging of Inflammatory Diseases of the Hands. Diagnostics 2022, 12, 1775. https://doi.org/10.3390/diagnostics12081775

AMA Style

Gedat E, Berger J, Kiesel D, Failli V, Briel A, Welker P. Features Found in Indocyanine Green-Based Fluorescence Optical Imaging of Inflammatory Diseases of the Hands. Diagnostics. 2022; 12(8):1775. https://doi.org/10.3390/diagnostics12081775

Chicago/Turabian Style

Gedat, Egbert, Jörn Berger, Denise Kiesel, Vieri Failli, Andreas Briel, and Pia Welker. 2022. "Features Found in Indocyanine Green-Based Fluorescence Optical Imaging of Inflammatory Diseases of the Hands" Diagnostics 12, no. 8: 1775. https://doi.org/10.3390/diagnostics12081775

APA Style

Gedat, E., Berger, J., Kiesel, D., Failli, V., Briel, A., & Welker, P. (2022). Features Found in Indocyanine Green-Based Fluorescence Optical Imaging of Inflammatory Diseases of the Hands. Diagnostics, 12(8), 1775. https://doi.org/10.3390/diagnostics12081775

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