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Diagnostics
Volume 12
Issue 2
10.3390/diagnostics12020371
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Brief Report

Unusual Histology in Mesothelioma: A Report of Two Cases with a Brief Review

by
Francesca Bono
1,*,
Stefano Ceola
2,
Carlo Beretta
2 and
Marta Jaconi
1
1
Pathology Unit, San Gerardo Hospital, 20900 Monza, Italy
2
Department of Medicine and Surgery, Pathology, San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(2), 371; https://doi.org/10.3390/diagnostics12020371
Submission received: 1 December 2021 / Revised: 29 December 2021 / Accepted: 14 January 2022 / Published: 1 February 2022
(This article belongs to the Special Issue Recent Advances in Diagnosis of Malignant Mesothelioma)
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Abstract

Mesothelioma is often difficult to diagnose due to its rarity and its unusual histopathological features that could lend to diagnostic pitfalls and misdiagnosis. The WHO histological classification of pleural tumors in 2021 recommended a pathologic grading system for malignant pleural mesothelioma. Architectural aspects and cytological features, with nuclear grading, bent on a neoplastic score with fundamental prognostic and diagnostic value. Unusual features must be correctly assigned in the grading system to avoid misdiagnosis, especially toward metastatic lesions or reactive pleural processes. In this paper, we present two cases as examples of unusual morphological and architectural features with a brief literature review.
Keywords: mesothelioma; adenomatoid mesothelioma; signet ring cell mesothelioma; unusual variant epithelioid mesothelioma mesothelioma; adenomatoid mesothelioma; signet ring cell mesothelioma; unusual variant epithelioid mesothelioma

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MDPI and ACS Style

Bono, F.; Ceola, S.; Beretta, C.; Jaconi, M. Unusual Histology in Mesothelioma: A Report of Two Cases with a Brief Review. Diagnostics 2022, 12, 371. https://doi.org/10.3390/diagnostics12020371

AMA Style

Bono F, Ceola S, Beretta C, Jaconi M. Unusual Histology in Mesothelioma: A Report of Two Cases with a Brief Review. Diagnostics. 2022; 12(2):371. https://doi.org/10.3390/diagnostics12020371

Chicago/Turabian Style

Bono, Francesca, Stefano Ceola, Carlo Beretta, and Marta Jaconi. 2022. "Unusual Histology in Mesothelioma: A Report of Two Cases with a Brief Review" Diagnostics 12, no. 2: 371. https://doi.org/10.3390/diagnostics12020371

APA Style

Bono, F., Ceola, S., Beretta, C., & Jaconi, M. (2022). Unusual Histology in Mesothelioma: A Report of Two Cases with a Brief Review. Diagnostics, 12(2), 371. https://doi.org/10.3390/diagnostics12020371

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