Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Selection Criteria and Ground Truth
2.2. B-Mode and Shear-Wave Elastography Imaging
2.3. Image Analysis for Shear-Wave Elastography
2.3.1. Local Average SWE Metrics
2.3.2. RGB Histogram
2.4. Statistics and Software
3. Result
3.1. RGB Histograms Discriminate Malignant from Benign Tumors
3.2. The Reduction of Soft-Tissue Components Is a Potential Biomarker for Breast Malignancy
3.3. Receiver Operating Curves for RGB Histograms
4. Discussion
4.1. Discriminative Value of the Local SWE Average, State of the Art
4.2. The Role of Anisotropy in Tumor Classification
4.3. Histogram SWE Analysis, Experience from Previous Studies, and the Role of Deep Learning
4.4. Effect of the ROI Size and Surrounding Tissue in SWE Interpretation
4.5. Study Weaknesses
5. Conclusions and Clinical Significance
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AI | Artificial intelligence |
ANOVA | Analysis of variance |
AUC | Area under curve |
CA | Cancer |
CIS | Cancer in situ |
FA | Fibroadenoma |
RGB | Red-green-blue |
ROC | Receiver operating curve |
ROI | Region of interest |
SD | Standard deviation |
SE | Strain elastography |
Se | Sensitivity |
Spe | Specificity |
SWE | Shear-wave elastography |
SWEavg | Average stiffness in kPa |
SWEmax | Maximum stiffness in kPa |
SWEref | Average stiffness of the reference region in kPa |
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Papageorgiou, I.; Valous, N.A.; Hadjidemetriou, S.; Teichgräber, U.; Malich, A. Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms. Diagnostics 2022, 12, 3140. https://doi.org/10.3390/diagnostics12123140
Papageorgiou I, Valous NA, Hadjidemetriou S, Teichgräber U, Malich A. Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms. Diagnostics. 2022; 12(12):3140. https://doi.org/10.3390/diagnostics12123140
Chicago/Turabian StylePapageorgiou, Ismini, Nektarios A. Valous, Stathis Hadjidemetriou, Ulf Teichgräber, and Ansgar Malich. 2022. "Quantitative Assessment of Breast-Tumor Stiffness Using Shear-Wave Elastography Histograms" Diagnostics 12, no. 12: 3140. https://doi.org/10.3390/diagnostics12123140