Evaluation and Clinical Impact of Biofire FilmArray Pneumonia Panel Plus in ICU-Hospitalized COVID-19 Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Variables | Patients (n = 105) |
---|---|
Male Sex | 79 (75.2%) |
Age (years) | 64 (30–80) |
Hospitalization days | 31 (8–136) |
ICU stay (days) | 21 (3–102) |
Hospital mortality | 1 (0.9%) |
ICU mortality | 21 (23.8%) |
Mechanical ventilation | 105 (99.3%) |
Leukocytosis | 65 (45.1%) |
Elevated procalcitonin levels | 27 (18.7%) |
Elevated CRP | 64 (44.4%) |
Impaired kidney functions | 36 (12.5%) |
Sensitivity | Specificity | PPV | NPV | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Pathogens | TP/(TP + FN) | TN/(TN + FP) | TP/(TP + FP) | TN/(TN + FN) | |||||||||
Pathogen | Total | TP | FN | FP | TN | % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI |
H. influenzae | 25 | 8 | - | 17 | 119 | 100 | 67.6–100 | 87.5 | 80.9–92.0 | 32 | 17.2–51.6 | 100 | 96.9–100 |
S. aureus | 16 | 11 | - | 5 | 128 | 100 | 74.1–100 | 96.2 | 91.5–98.4 | 68.8 | 44.4–85.8 | 100 | 97.1–100 |
P. aeruginosa | 10 | 7 | - | 3 | 134 | 100 | 64.6–100 | 97.8 | 93.8–99.3 | 70 | 39.7–89.2 | 100 | 97.2–100 |
S. pneumoniae | 8 | 4 | 3 | 1 | 136 | 57.1 | 25.0–84.2 | 99.3 | 95.4–99.9 | 80 | 37.6–96.4 | 97.5 | 93–99.2 |
K. pneumoniae | 6 | 3 | - | 3 | 138 | 100 | 43.9–100 | 97.9 | 93.9–99.3 | 50 | 18.8–81.2 | 100 | 97.3–100 |
E. coli | 5 | 2 | - | 3 | 139 | 100 | 34.2–100 | 97.9 | 94–99.3 | 40 | 11.8–76.9 | 100 | 97.3–100 |
E. cloacae | 3 | 3 | - | - | 141 | 100 | 43.9–100 | 100 | 97.3–100 | 100 | 43.9–100 | 100 | 97.3–100 |
S. marcescens | 2 | 1 | - | 1 | 142 | 100 | 20.7–100 | 99.3 | 96.1–99.9 | 50 | 9.5–90.5 | 100 | 97.4–100 |
S. agalactiae | 2 | - | - | 2 | 142 | -- | -- | 98.6 | 95.1–99.6 | 0 | 0–65.8 | 100 | 97.4–100 |
K. aerogenes | 2 | - | - | 2 | 142 | -- | -- | 98.6 | 95.1–99.6 | 0 | 0–65.8 | 100 | 97.4–100 |
M. catarrhalis | 2 | - | - | 2 | 142 | -- | -- | 98.6 | 95.1–99.6 | 0 | 0–65.8 | 100 | 97.4–100 |
Total | 81 | 39 | 3 | 39 | 63 | 92.9 | 81.0–97.5 | 61.8 | 52.1–70.6 | 50 | 39.2–60.8 | 95.5 | 87.5–98.4 |
Pathogen | Admission | Superinfection | Total |
---|---|---|---|
H. influenzae | 13 | 12 | 25 |
S. aureus | 7 | 9 | 16 |
P. aeruginosa | - | 10 | 10 |
S. pneumoniae | 4 | 1 | 8 |
K. pneumoniae | - | 6 | 6 |
E. coli | 1 | 4 | 5 |
E. cloacae | 1 | 2 | 3 |
S. marcescens | - | 2 | 2 |
S. agalactiae | 2 | - | 2 |
K. aerogenes | - | 2 | 2 |
M. catarrhalis | 2 | - | 2 |
TOTAL | 30 | 48 | 78 |
CC Count (fpu/mL) | FAPP+ Count (Copies/mL) | ||||
---|---|---|---|---|---|
≥107 | 106 | 105 | 104 | No Detected | |
>106 | 19 | 2 | - | - | 2 |
106 | 3 | 4 | - | - | 1 |
105 | 3 | 5 | 3 | - | - |
No detected | 8 | 7 | 15 | 9 | - |
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Escudero, D.; Fernández-Suarez, J.; Forcelledo, L.; Balboa, S.; Fernández, J.; Astola, I.; Quindos, B.; Campos, R.; Vázquez, F.; Boga, J.A. Evaluation and Clinical Impact of Biofire FilmArray Pneumonia Panel Plus in ICU-Hospitalized COVID-19 Patients. Diagnostics 2022, 12, 3134. https://doi.org/10.3390/diagnostics12123134
Escudero D, Fernández-Suarez J, Forcelledo L, Balboa S, Fernández J, Astola I, Quindos B, Campos R, Vázquez F, Boga JA. Evaluation and Clinical Impact of Biofire FilmArray Pneumonia Panel Plus in ICU-Hospitalized COVID-19 Patients. Diagnostics. 2022; 12(12):3134. https://doi.org/10.3390/diagnostics12123134
Chicago/Turabian StyleEscudero, Dolores, Jonathan Fernández-Suarez, Lorena Forcelledo, Salvador Balboa, Javier Fernández, Ivan Astola, Brigida Quindos, Rainer Campos, Fernando Vázquez, and José Antonio Boga. 2022. "Evaluation and Clinical Impact of Biofire FilmArray Pneumonia Panel Plus in ICU-Hospitalized COVID-19 Patients" Diagnostics 12, no. 12: 3134. https://doi.org/10.3390/diagnostics12123134