Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy and Identification of Eligible Studies
2.2. Inclusion and Exclusion Criteria
2.3. Data Extraction and Appraisal of Methodological Quality
2.4. Outcomes
2.5. Statistical Analysis and Data Synthesis
3. Results
3.1. Association of NLR with Osteoporosis
3.1.1. Mean Difference in NLR between the Osteoporosis and Normal BMD Groups
3.1.2. Subgroup Analysis
3.1.3. Meta Regression
3.2. Association of PLR with Osteoporosis
Mean Difference in PLR between the Osteoporosis and Normal BMD Groups
3.3. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author (Year) | Country | Study Design | Sample (N) | Female (n, %) | Mean Age (Years) | Methodology for BMD Measurement; Site | Model |
---|---|---|---|---|---|---|---|
Eroglu et al., (2019) [18] | Turkey | cross-sectional | 140 | 140, 100% | 54.21 | DEXA; lumbar spine, total femur, femoral neck | NLR, PLR |
Gao et al., (2019) [19] | China | cross-sectional | 210 | 119, 56.7% | 57.16 | DEXA; lumbar spine, femoral neck | NLR, PLR |
Huang et al., (2016) [20] | China | cross-sectional | 173 | 173, 100% | 62.2 | DEXA; lumbar spine, left total femur | NLR |
Kale et al., (2021) [21] | Turkey | cross-sectional | 74 | 74, 100% | 59.62 | DEXA; lumbar spine, femoral neck | NLR, PLR |
Onalan et al., (2020) [22] | Turkey | cross-sectional | 215 | 177, 82.3% | 73.73 | DEXA; not declared | NLR, PLR |
Ozturk et al., (2013) [23] | Turkey | cross-sectional | 1011 | 608, 60.1% | 72.63 | DEXA; lumbar spine, total femur, femoral neck | NLR |
Qin et al., (2021) [24] | China | cross-sectional | 29 | 20, 69.0% | 59.96 | QCT; not declared | NLR |
Salmani et al., (2021) [17] | Oman | cross-sectional | 286 | 286, 100% | 64.41 | DEXA; lumbar spine, pelvis, femoral neck | NLR, PLR |
Seo et al., (2009) [25] | Korea | cross-sectional | 66 | 66, 100% | 56.53 | DEXA; lumbar spine, proximal femur | NLR |
Yu et al., (2015) [26] | China | cross-sectional | 412 | 412, 100% | 74.95 | DEXA; lumbar spine, femoral neck | NLR |
Moderators | Regression Coefficient | 95% CI, Lower Limit | 95% CI, Upper Limit | p Value |
---|---|---|---|---|
Age | −0.0083 | −0.0312 | 0.0146 | 0.478 |
DM * | −0.1417 | −0.5044 | 0.2209 | 0.444 |
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Liu, Y.-C.; Yang, T.-I.; Huang, S.-W.; Kuo, Y.-J.; Chen, Y.-P. Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis. Diagnostics 2022, 12, 2968. https://doi.org/10.3390/diagnostics12122968
Liu Y-C, Yang T-I, Huang S-W, Kuo Y-J, Chen Y-P. Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis. Diagnostics. 2022; 12(12):2968. https://doi.org/10.3390/diagnostics12122968
Chicago/Turabian StyleLiu, Yu-Cheng, Tzu-I Yang, Shu-Wei Huang, Yi-Jie Kuo, and Yu-Pin Chen. 2022. "Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis" Diagnostics 12, no. 12: 2968. https://doi.org/10.3390/diagnostics12122968