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Diagnostics
Volume 12
Issue 10
10.3390/diagnostics12102501
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Review

Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS)

by
Safak Hatirnaz
1,*,
Ebru Hatirnaz
1,
Samettin Çelik
2,
Canan Soyer Çalışkan
2,
Andrea Tinelli
3,*,
Antonio Malvasi
4,
Radmila Sparic
5,
Domenico Baldini
6,
Michael Stark
7 and
Michael H. Dahan
8
1
Mediliv Medical Center, Samsun 55100, Turkey
2
Department of Obstetrics and Gynecology, Samsun Training and Research Hospital, Samsun 55090, Turkey
3
Department of Obstetrics and Gynecology and CERICSAL (CEntro di RIcercaClinicoSALentino), Verisdelli Ponti Hospital, 73020 Scorrano, Italy
4
Department of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Section, University of Bari “Aldo Moro”, Piazza Aldo Moro, 70100 Bari, Italy
5
Medical Faculty, Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, University of Belgrade, 11000 Belgrade, Serbia
6
MomòFertilife Clinic, 76011 Bisceglie, Italy
7
The New European Surgical Academy (NESA), 10117 Berlin, Germany
8
McGill University Health Center Reproductive Centre, Department of ObGyn, McGill University, Montreal, QC H3A 0G4, Canada
*
Authors to whom correspondence should be addressed.
Diagnostics 2022, 12(10), 2501; https://doi.org/10.3390/diagnostics12102501
Submission received: 31 August 2022 / Revised: 12 October 2022 / Accepted: 12 October 2022 / Published: 15 October 2022
(This article belongs to the Special Issue Predictive and Prognostic Biomarkers of Human Cancer in Italy)
Review Reports Versions Notes

Abstract

Oocyte maturation abnormalities (OMAS) are a poorly understood area of reproductive medicine. Much remains to be understood about how OMAS occur. However, current knowledge has provided some insight into the mechanistic and genetic origins of this syndrome. In this study, current classifications of OMAS syndromes are discussed and areas of inadequacy are highlighted. We explain why empty follicle syndrome, dysmorphic oocytes, some types of premature ovarian insufficiency and resistant ovary syndrome can cause OMAS. We discuss live births in different types of OMAS and when subjects can be offered treatment with autologous oocytes. As such, we present this review of the mechanism and understanding of OMAS to better lead the clinician in understanding this difficult-to-treat diagnosis.
Keywords: oocyte maturation; oocyte maturation abnormalities; empty follicle syndrome; FSH; LH; fertility; stimulation; meiosis; metaphase; meiotic arrest; premature ovarian failure; resistant ovarian syndrome oocyte maturation; oocyte maturation abnormalities; empty follicle syndrome; FSH; LH; fertility; stimulation; meiosis; metaphase; meiotic arrest; premature ovarian failure; resistant ovarian syndrome

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MDPI and ACS Style

Hatirnaz, S.; Hatirnaz, E.; Çelik, S.; Çalışkan, C.S.; Tinelli, A.; Malvasi, A.; Sparic, R.; Baldini, D.; Stark, M.; Dahan, M.H. Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS). Diagnostics 2022, 12, 2501. https://doi.org/10.3390/diagnostics12102501

AMA Style

Hatirnaz S, Hatirnaz E, Çelik S, Çalışkan CS, Tinelli A, Malvasi A, Sparic R, Baldini D, Stark M, Dahan MH. Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS). Diagnostics. 2022; 12(10):2501. https://doi.org/10.3390/diagnostics12102501

Chicago/Turabian Style

Hatirnaz, Safak, Ebru Hatirnaz, Samettin Çelik, Canan Soyer Çalışkan, Andrea Tinelli, Antonio Malvasi, Radmila Sparic, Domenico Baldini, Michael Stark, and Michael H. Dahan. 2022. "Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS)" Diagnostics 12, no. 10: 2501. https://doi.org/10.3390/diagnostics12102501

APA Style

Hatirnaz, S., Hatirnaz, E., Çelik, S., Çalışkan, C. S., Tinelli, A., Malvasi, A., Sparic, R., Baldini, D., Stark, M., & Dahan, M. H. (2022). Unraveling the Puzzle: Oocyte Maturation Abnormalities (OMAS). Diagnostics, 12(10), 2501. https://doi.org/10.3390/diagnostics12102501

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