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Article

Information Processing Speed Assessed with Letter Digit Substitution Test in Croatian Sample of Multiple Sclerosis Patients

1
Laboratory for Human and Experimental Neurophysiology (LAHEN), Department of Neuroscience, School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia
2
Department of Neurology, University Hospital of Split, Spinčićeva 1, 21000 Split, Croatia
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Department of Psychology, University of Zadar, Ul. Mihovila Pavlinovića, 23000 Zadar, Croatia
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Department of Radiology, University Hospital of Split, Spinčićeva 1, 21000 Split, Croatia
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General Hospital Zadar, Neurology, Ul. Bože Peričića 5, 23000 Zadar, Croatia
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Signal Processing, Analysis, Advanced Diagnostics Research and Education Laboratory (SPAADREL), Faculty of Maritime Studies, University of Split, Ul. Ruđera Boškovića 37, 21000 Split, Croatia
7
Split Sleep Medical Centre, University Hospital of Split, 21000 Split, Croatia
*
Author to whom correspondence should be addressed.
Academic Editors: Robert Živadinov and Dejan Jakimovski
Diagnostics 2022, 12(1), 111; https://doi.org/10.3390/diagnostics12010111
Received: 30 November 2021 / Revised: 29 December 2021 / Accepted: 30 December 2021 / Published: 4 January 2022
(This article belongs to the Special Issue Multiple Sclerosis Diagnostics)
Cognitive impairment is a common complaint in people with multiple sclerosis (pwMS). The study objective was to determine the psychometric properties of the letter digit substitution test (LDST) that measures information processing speed and to investigate the impact of relevant predictors of LDST achievement in pwMS. The design was cross-sectional. The study included 87 pwMS and 154 control subjects. The validity of LDST was examined, and a hierarchical regression model was used to explore relevant predictors of LDST success. The LDST had excellent construct validity, as expressed by differences between pwMS and control subjects. Convergent validity of the LDST was supported by a significant moderate correlation with the expanded disability status scale (EDSS) (ρ = −0.36; p < 0.05) and a significantly strong correlation with the multiple sclerosis impact scale (MSIS-29) physical subscale (r = −0.64; p < 0.01). The LDTS score well differentiated the pwMS considering age, education, EDSS, disease duration, comorbidity, and medication therapy. Using the LDST as a criterion variable in pwMS results showed consistent evidence for the age, education, and EDSS impact on LDST performance. The best cut-off score of ≤35 discriminated the control and MS group. LDST proved to be a valid test for assessing information processing speed in pwMS. View Full-Text
Keywords: multiple sclerosis; cognition; cognitive measure; information processing speed; Letter Digit Substitution Test multiple sclerosis; cognition; cognitive measure; information processing speed; Letter Digit Substitution Test
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MDPI and ACS Style

Jerković, A.; Matijaca, M.; Proroković, A.; Šikić, A.; Košta, V.; Ćurković Katić, A.; Dolić, K.; Duka Glavor, K.; Šoda, J.; Đogaš, Z.; Rogić Vidaković, M. Information Processing Speed Assessed with Letter Digit Substitution Test in Croatian Sample of Multiple Sclerosis Patients. Diagnostics 2022, 12, 111. https://doi.org/10.3390/diagnostics12010111

AMA Style

Jerković A, Matijaca M, Proroković A, Šikić A, Košta V, Ćurković Katić A, Dolić K, Duka Glavor K, Šoda J, Đogaš Z, Rogić Vidaković M. Information Processing Speed Assessed with Letter Digit Substitution Test in Croatian Sample of Multiple Sclerosis Patients. Diagnostics. 2022; 12(1):111. https://doi.org/10.3390/diagnostics12010111

Chicago/Turabian Style

Jerković, Ana, Meri Matijaca, Ana Proroković, Anđela Šikić, Vana Košta, Ana Ćurković Katić, Krešimir Dolić, Klaudia Duka Glavor, Joško Šoda, Zoran Đogaš, and Maja Rogić Vidaković. 2022. "Information Processing Speed Assessed with Letter Digit Substitution Test in Croatian Sample of Multiple Sclerosis Patients" Diagnostics 12, no. 1: 111. https://doi.org/10.3390/diagnostics12010111

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