Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis

Deding, Ulrik; Cortegoso Valdivia, Pablo; Koulaouzidis, Anastasios; Baatrup, Gunnar; Toth, Ervin; Spada, Cristiano; Fernández-Urién, Ignacio; Pennazio, Marco; Bjørsum-Meyer, Thomas

doi:10.3390/diagnostics11091730

Open AccessReview

Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis

by

Ulrik Deding

^1,2,*

,

Pablo Cortegoso Valdivia

³

,

Anastasios Koulaouzidis

⁴

,

Gunnar Baatrup

^1,2,

Ervin Toth

⁵

,

Cristiano Spada

⁶,

Ignacio Fernández-Urién

⁷,

Marco Pennazio

⁸

and

Thomas Bjørsum-Meyer

^1,2

¹

Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark

²

Department of Surgery, Odense University Hospital, 5000 Odense, Denmark

³

Gastroenterology and Endoscopy Unit, University Hospital of Parma, University of Parma, 43121 Parma, Italy

⁴

Department of Social Medicine & Public Health, Faculty of Health Sciences, Pomeranian Medical University, 70-204 Szczecin, Poland

⁵

Department of Gastroenterology, Skåne University Hospital, Lund University, 221 00 Malmö, Sweden

⁶

Digestive Endoscopy Unit, Fondazione Poliambulanza Istituto Ospedaliero, 25133 Brescia, Italy

⁷

Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain

⁸

University Division of Gastroenterology, AOU Città Della Salute e Della Scienza, University of Turin, 10124 Turin, Italy

^*

Author to whom correspondence should be addressed.

Diagnostics 2021, 11(9), 1730; https://doi.org/10.3390/diagnostics11091730

Submission received: 20 August 2021 / Revised: 15 September 2021 / Accepted: 18 September 2021 / Published: 20 September 2021

(This article belongs to the Special Issue Capsule Endoscopy: Clinical Impacts and Innovation since 2001)

Download

Browse Figures

Versions Notes

Abstract

Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in- and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including univariate meta-regressions. Patient-reported tolerability and adverse events were reviewed. Out of fourteen included studies, twelve had investigated patient-reported outcomes in patients who had undergone both investigations, whereas in two the patients were randomized between investigations. Pooled patient preferences were estimated to be 52% (CI 95%: 41–63%) for colon capsule endoscopy and 45% (CI 95%: 33–57%) for conventional colonoscopy: not indicating a significant difference. Procedural adverse events were rarely reported by patients for either investigation. The tolerability was high for both colon capsule endoscopy and conventional colonoscopy. Patient preferences for conventional colonoscopy and colon capsule endoscopy were not significantly different. Procedural adverse events were rare and the tolerability for colon capsule endoscopy was consistently reported higher or equal to that of conventional colonoscopy.

Keywords: colonoscopy; colon capsule endoscopy; patient-reported outcomes; endoscopy

Share and Cite

MDPI and ACS Style

Deding, U.; Cortegoso Valdivia, P.; Koulaouzidis, A.; Baatrup, G.; Toth, E.; Spada, C.; Fernández-Urién, I.; Pennazio, M.; Bjørsum-Meyer, T. Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis. Diagnostics 2021, 11, 1730. https://doi.org/10.3390/diagnostics11091730

AMA Style

Deding U, Cortegoso Valdivia P, Koulaouzidis A, Baatrup G, Toth E, Spada C, Fernández-Urién I, Pennazio M, Bjørsum-Meyer T. Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis. Diagnostics. 2021; 11(9):1730. https://doi.org/10.3390/diagnostics11091730

Chicago/Turabian Style

Deding, Ulrik, Pablo Cortegoso Valdivia, Anastasios Koulaouzidis, Gunnar Baatrup, Ervin Toth, Cristiano Spada, Ignacio Fernández-Urién, Marco Pennazio, and Thomas Bjørsum-Meyer. 2021. "Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis" Diagnostics 11, no. 9: 1730. https://doi.org/10.3390/diagnostics11091730

APA Style

Deding, U., Cortegoso Valdivia, P., Koulaouzidis, A., Baatrup, G., Toth, E., Spada, C., Fernández-Urién, I., Pennazio, M., & Bjørsum-Meyer, T. (2021). Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis. Diagnostics, 11(9), 1730. https://doi.org/10.3390/diagnostics11091730

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI