TREC/KREC Levels in Young COVID-19 Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. DNA Extraction and Quantitative PCR Assay
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Total Patients (n = 36) |
---|---|
Age, years | 38.50 (31.00–44.00) |
Male | 21 (58.3%) |
Hypertension | 8 (22.22%) |
Diabetes mellitus | 3 (8.33%) |
Body mass index, kg/m2 | 28.80 (23.90–40.90) |
Missing, n (%) | 14 (38.89%) |
Time from onset of illness to hospitalization, days | 6.50 (1.00–12.00) |
Length of stay in hospital/ICU, days | 15.50 (8.00–29.00) |
SpO2, ≤93% | 16 (44.44%) |
Missing, n (%) | 2 (5.56%) |
Symptoms: | |
Fever | 22 (61.11%) |
Cough | 24 (66.67%) |
Sore throat | 4 (11.11%) |
Chest tightness or chest pain | 4 (11.11%) |
Fatigue | 31 (86.11%) |
Chills | 5 (13.89%) |
Dyspnea | 13 (36.11%) |
Myalgia | 4 (11.11%) |
Vomiting or nausea | 3 (8.33%) |
Diarrhea | 4 (11.11%) |
Headache | 6 (16.67%) |
Loss of smell or taste | 7 (19.44%) |
CT score: | |
0–1 | 16 (44.44%) |
2 | 11 (30.56%) |
3 | 6 (16.67%) |
4 | 3 (8.33%) |
ARDS: | 10 (27.78%) |
mild | 2/10 (20.00%) |
moderate | 4/10 (40.00%) |
severe | 4/10 (40.00%) |
Non-Survivors | 4 (11.11%) |
Variable | Non-ARDS (n = 26) | ARDS (n = 10) | p-Value | FDR Adjusted p-Value |
---|---|---|---|---|
TREC/100,000 cells | 69.04 (15.43–230.60) | 8.75 (0.00–259.56) | 0.045 | 0.049 |
TREC/WBC in 1 µL of blood | 4.40 (0.55–11.70) | 0.76 (0.00–13.83) | 0.049 | 0.049 |
TREC/lymphocytes in 1 µL of blood | 0.09 (0.01–0.33) | 0.01 (0.00–0.34) | 0.026 | 0.039 |
KREC/100,000 cells | 705.18 (86.64–1532.52) | 160.76 (22.83–537.99) | 0.002 | 0.006 |
KREC/WBC in 1 µL of blood | 44.64 (5.50–127.93) | 13.57 (2.10–29.74) | 0.003 | 0.006 |
KREC/lymphocytes in 1 µL of blood | 14.01 (1.99–39.48) | 0.88 (0.23–39.48) | 0.003 | 0.006 |
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Khadzhieva, M.B.; Kalinina, E.V.; Larin, S.S.; Sviridova, D.A.; Gracheva, A.S.; Chursinova, J.V.; Stepanov, V.A.; Redkin, I.V.; Avdeikina, L.S.; Rumyantsev, A.G.; et al. TREC/KREC Levels in Young COVID-19 Patients. Diagnostics 2021, 11, 1486. https://doi.org/10.3390/diagnostics11081486
Khadzhieva MB, Kalinina EV, Larin SS, Sviridova DA, Gracheva AS, Chursinova JV, Stepanov VA, Redkin IV, Avdeikina LS, Rumyantsev AG, et al. TREC/KREC Levels in Young COVID-19 Patients. Diagnostics. 2021; 11(8):1486. https://doi.org/10.3390/diagnostics11081486
Chicago/Turabian StyleKhadzhieva, Maryam B., Ekaterina V. Kalinina, Sergey S. Larin, Daria A. Sviridova, Alesya S. Gracheva, Julia V. Chursinova, Vadim A. Stepanov, Ivan V. Redkin, Lyudmila S. Avdeikina, Alexander G. Rumyantsev, and et al. 2021. "TREC/KREC Levels in Young COVID-19 Patients" Diagnostics 11, no. 8: 1486. https://doi.org/10.3390/diagnostics11081486
APA StyleKhadzhieva, M. B., Kalinina, E. V., Larin, S. S., Sviridova, D. A., Gracheva, A. S., Chursinova, J. V., Stepanov, V. A., Redkin, I. V., Avdeikina, L. S., Rumyantsev, A. G., Kuzovlev, A. N., & Salnikova, L. E. (2021). TREC/KREC Levels in Young COVID-19 Patients. Diagnostics, 11(8), 1486. https://doi.org/10.3390/diagnostics11081486