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Brief Report

Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test

1
Scientific Direction, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
2
Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
3
Unit of Internal Medicine “Guido Baccelli”, Department of Biomedical Sciences and Human Oncology, University of Bari, 70124 Bari, Italy
4
Medical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
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Experimental Oncology and Biobank Management Unit, Institutional BioBank, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
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Hygiene Unit, University Hospital “Policlinico” of Bari, 70124 Bari, Italy
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Professioni Sanitarie Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
8
Clinical Pathology Laboratory, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Renato Millioni
Diagnostics 2021, 11(6), 975; https://doi.org/10.3390/diagnostics11060975
Received: 19 April 2021 / Revised: 21 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021
Health-care workers (HCW) are at high risk for SARS-CoV-2 infection and, if asymptomatic, for transmitting the virus to fragile cancer patients. We monitored all asymptomatic HCWs of a cancer institute (94% of all employees agreed to enter the study) with the rapid serological test, VivaDiagTM, identifying SARS-CoV-2 associated-IgM/IgG. The tests were performed at time 0 (n = 606) and after 14 days (n = 393). Overall, the VivaDiagTM results of nine HCWs (1.5%) were positive, with one confirmed to be SARS-CoV-2-positive after oropharyngeal swab testing by RT-PCR. At time 0, all nine cases showed IgM expression while IgG was detected in only one. After 14 days, IgM persisted in all the cases, while IgG became evident in four. A chemiluminescence immunoassay (CLIA) confirmed IgM positivity in 5/13 VivaDiagTM positive cases and IgG positivity in 4/5 VivaDiagTM positive cases. Our study suggests that the VivaDiagTM test can be of help in identifying SARS-CoV-2 infected people in cohorts of subjects with a high prevalence. View Full-Text
Keywords: COVID-19; SARS-CoV-2; serological test; health-care workers; cancer center COVID-19; SARS-CoV-2; serological test; health-care workers; cancer center
MDPI and ACS Style

Paradiso, A.V.; De Summa, S.; Silvestris, N.; Tommasi, S.; Tufaro, A.; Larocca, A.M.V.; D’Addabbo, V.; Raffaele, D.; Cafagna, V.; Garrisi, V.M.; De Palma, G. Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test. Diagnostics 2021, 11, 975. https://doi.org/10.3390/diagnostics11060975

AMA Style

Paradiso AV, De Summa S, Silvestris N, Tommasi S, Tufaro A, Larocca AMV, D’Addabbo V, Raffaele D, Cafagna V, Garrisi VM, De Palma G. Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test. Diagnostics. 2021; 11(6):975. https://doi.org/10.3390/diagnostics11060975

Chicago/Turabian Style

Paradiso, Angelo V., Simona De Summa, Nicola Silvestris, Stefania Tommasi, Antonio Tufaro, Angela M.V. Larocca, Vincenzo D’Addabbo, Donata Raffaele, Vito Cafagna, Vito M. Garrisi, and Giuseppe De Palma. 2021. "Prospective Observational COVID-19 Screening and Monitoring of Asymptomatic Cancer Center Health-Care Workers with a Rapid Serological Test" Diagnostics 11, no. 6: 975. https://doi.org/10.3390/diagnostics11060975

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