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Volume 11
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10.3390/diagnostics11061036
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Article

Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses

by
Jara Pascual-Mancho
1,2,3,4,†,
Pilar Pintado-Recarte
1,2,3,†,
Carlos Romero-Román
5,
Jorge C. Morales-Camino
5,
Concepción Hernández-Martin
1,2,3,
Julia Bujan
6,7,
Miguel A. Ortega
6,7,8,* and
Juan De León-Luis
1,2,3
1
Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
2
Department of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, Spain
3
Health Research Institute Gregorio Marañón, 28009 Madrid, Spain
4
Department of Obstetrics, Prenatal Diagnosis, Miguel Servet University Hospital, 50009 Zaragoza, Spain
5
Laboratory of Clinical Biochemistry, Albacete Hospital, 02006 Albacete, Spain
6
Ramón y Cajal Institute of Healthcare Research (IRYCIS), 28034 Madrid, Spain
7
Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28801 Madrid, Spain
8
Pathological Anatomy Service, Central University Hospital of Defense-UAH, 28047 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
These authors contribution equality to this work.
Diagnostics 2021, 11(6), 1036; https://doi.org/10.3390/diagnostics11061036
Submission received: 15 April 2021 / Revised: 26 May 2021 / Accepted: 2 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Maternal-Fetal Medicine)
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Abstract

Fetal growth restriction (FGR) is one of the most important obstetric pathologies. It is frequently caused by placental insufficiency. Previous studies have shown a relationship between FGR and impaired new-born neurodevelopment, although the molecular mechanisms involved in this association have not yet been completely clarified. Reelin is an extracellular matrix glycoprotein involved in development of neocortex, hippocampus, cerebellum and spinal cord. Reelin has been demonstrated to play a key role in regulating perinatal neurodevelopment and to contribute to the emergence and development of various psychiatric pathologies, and its levels are highly influenced by pathological conditions of hypoxia. The purpose of this article is to study whether reelin levels in new-borns vary as a function of severity of fetal growth restriction by gestational age and sex. We sub-grouped fetuses in: normal weight group (Group 1, n = 17), FGR group with normal umbilical artery Doppler and cerebral redistribution at middle cerebral artery Doppler (Group 2, n = 9), and FGR with abnormal umbilical artery Doppler (Group 3, n = 8). Our results show a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on further expanding the knowledge of the relationship of reelin and its regulated products with neurodevelopment impairment in new-borns with FGR and should include larger and more homogeneous samples and the combined use of different in vivo techniques in neonates with impaired growth during their different adaptive phases.
Keywords: intrauterine growth restriction; perinatal neurodevelopment; reelin; hypoxia intrauterine growth restriction; perinatal neurodevelopment; reelin; hypoxia

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MDPI and ACS Style

Pascual-Mancho, J.; Pintado-Recarte, P.; Romero-Román, C.; Morales-Camino, J.C.; Hernández-Martin, C.; Bujan, J.; Ortega, M.A.; De León-Luis, J. Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses. Diagnostics 2021, 11, 1036. https://doi.org/10.3390/diagnostics11061036

AMA Style

Pascual-Mancho J, Pintado-Recarte P, Romero-Román C, Morales-Camino JC, Hernández-Martin C, Bujan J, Ortega MA, De León-Luis J. Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses. Diagnostics. 2021; 11(6):1036. https://doi.org/10.3390/diagnostics11061036

Chicago/Turabian Style

Pascual-Mancho, Jara, Pilar Pintado-Recarte, Carlos Romero-Román, Jorge C. Morales-Camino, Concepción Hernández-Martin, Julia Bujan, Miguel A. Ortega, and Juan De León-Luis. 2021. "Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses" Diagnostics 11, no. 6: 1036. https://doi.org/10.3390/diagnostics11061036

APA Style

Pascual-Mancho, J., Pintado-Recarte, P., Romero-Román, C., Morales-Camino, J. C., Hernández-Martin, C., Bujan, J., Ortega, M. A., & De León-Luis, J. (2021). Influence of Cerebral Vasodilation on Blood Reelin Levels in Growth Restricted Fetuses. Diagnostics, 11(6), 1036. https://doi.org/10.3390/diagnostics11061036

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